| Entry |
|
|---|
| Name |
HIV Vpu/Vif/Vpr to cGAS-STING signaling pathway
|
|---|
| Definition |
(Vpu,Vif,Vpr) -| IRF3 |
|---|
| Expanded |
(K22890,K22892,K22202) -| 3661 |
|---|
| Class |
nt06520 CGAS-STING signaling
nt06161 Human immunodeficiency virus 1 (HIV-1)
|
|---|
| Type |
Pathogen
|
|---|
| Pathway |
| hsa05170 | Human immunodeficiency virus 1 infection |
|
|---|
| Disease |
|
|---|
| Gene |
| 3661 | IRF3; interferon regulatory factor 3 |
|
|---|
| Perturbant |
| K22890 (Vpu) | vpu; HIV-1 protein Vpu |
| K22892 (Vif) | vif; HIV-1 virion infectivity factor |
| K22202 (Vpr) | vpr; HIV-1 virus protein R |
|
|---|
| Reference |
|
|---|
| Authors |
Altfeld M, Gale M Jr |
|---|
| Title |
Innate immunity against HIV-1 infection. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Park SY, Waheed AA, Zhang ZR, Freed EO, Bonifacino JS |
|---|
| Title |
HIV-1 Vpu accessory protein induces caspase-mediated cleavage of IRF3 transcription factor. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Doehle BP, Chang K, Rustagi A, McNevin J, McElrath MJ, Gale M Jr |
|---|
| Title |
Vpu mediates depletion of interferon regulatory factor 3 during HIV infection by a lysosome-dependent mechanism. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Okumura A, Alce T, Lubyova B, Ezelle H, Strebel K, Pitha PM |
|---|
| Title |
HIV-1 accessory proteins VPR and Vif modulate antiviral response by targeting IRF-3 for degradation. |
|---|
| Journal |
|
|---|
| LinkDB |
|
|---|
