| Entry |
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| Name |
HIV Vpr to CDC25-cell cycle G2M
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| Definition |
Vpr == (DCAF1+DDB1+CUL4) -> ATR -> CHEK1 -| CDC25C -> (CCNB+CDK1) |
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| Expanded |
K22202 == (9730+1642+(8451,8450)) -> 545 -> 1111 -| 995 -> ((891,9133,85417)+983) |
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| Class |
nt06161 Human immunodeficiency virus 1 (HIV-1)
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| Type |
Pathogen
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| Pathway |
| hsa05170 | Human immunodeficiency virus 1 infection |
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| Disease |
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| Gene |
| 9730 | DCAF1; DDB1 and CUL4 associated factor 1 |
| 1642 | DDB1; damage specific DNA binding protein 1 |
| 545 | ATR; ATR serine/threonine kinase |
| 1111 | CHEK1; checkpoint kinase 1 |
| 995 | CDC25C; cell division cycle 25C |
| 983 | CDK1; cyclin dependent kinase 1 |
|
|---|
| Perturbant |
| K22202 (Vpr) | vpr; HIV-1 virus protein R |
|
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| Reference |
|
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| Authors |
Andersen JL, Le Rouzic E, Planelles V |
|---|
| Title |
HIV-1 Vpr: mechanisms of G2 arrest and apoptosis. |
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| Journal |
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| Reference |
|
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| Authors |
Bregnard C, Benkirane M, Laguette N |
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| Title |
DNA damage repair machinery and HIV escape from innate immune sensing. |
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| Journal |
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| Reference |
|
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| Authors |
DeHart JL, Zimmerman ES, Ardon O, Monteiro-Filho CM, Arganaraz ER, Planelles V |
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| Title |
HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system. |
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| Journal |
|
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| Reference |
|
|---|
| Authors |
Tan L, Ehrlich E, Yu XF |
|---|
| Title |
DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest. |
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| Journal |
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| LinkDB |
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