Homo sapiens (human): 1111 Help Entry 1111              CDS       T01001                                  Symbol CHEK1, CHK1, OZEMA21 Name (RefSeq) checkpoint kinase 1   KO K02216   serine/threonine-protein kinase CHEK1 [EC:2.7.11.1] Organism hsa  Homo sapiens (human) Pathway hsa04110   Cell cycle hsa04115   p53 signaling pathway hsa04218   Cellular senescence hsa05166   Human T-cell leukemia virus 1 infection hsa05170   Human immunodeficiency virus 1 infection hsa05203   Viral carcinogenesis Network   Element N00455   CDC25-Cell cycle G2/M N00456   HIV Vpr to CDC25-cell cycle G2M N00459   WEE1-Cell cycle G2/M N00499   ATR-p21-Cell cycle G2/M N00500   HTLV-1 Tax to p21-cell cycle G2/M N01451   ATR signaling Disease H01897   Oocyte/zygote/embryo maturation arrest Drug target Prexasertib:  D11206 Rabusertib:  D10397 Brite KEGG Orthology (KO) [BR:hsa00001]  09140 Cellular Processes   09143 Cell growth and death    04110 Cell cycle     1111 (CHEK1)    04115 p53 signaling pathway     1111 (CHEK1)    04218 Cellular senescence     1111 (CHEK1)  09160 Human Diseases   09161 Cancer: overview    05203 Viral carcinogenesis     1111 (CHEK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     1111 (CHEK1)    05170 Human immunodeficiency virus 1 infection     1111 (CHEK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     1111 (CHEK1)   09182 Protein families: genetic information processing    03400 DNA repair and recombination proteins [BR:hsa03400]     1111 (CHEK1) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      1111 (CHEK1) Protein kinases [BR:hsa01001]  Serine/threonine kinases: CAMK group   CAMKL family    1111 (CHEK1) DNA repair and recombination proteins [BR:hsa03400]  Eukaryotic type   Check point factors    Other check point factors     1111 (CHEK1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr Kinase-like ABC1 Pkinase_fungal Motif Other DBs NCBI-GeneID:  1111 NCBI-ProteinID:  NP_001107593 OMIM:  603078 HGNC:  1925 Ensembl:  ENSG00000149554 UniProt:  O14757 B4DT73 Structure PDB LinkDB All DBs Position 11:125625136..125681124 Genome browser AA seq 476 aa AA seqDB search MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT NT seq 1431 nt NT seq  +upstreamnt  +downstreamnt atggcagtgccctttgtggaagactgggacttggtgcaaaccctgggagaaggtgcctat ggagaagttcaacttgctgtgaatagagtaactgaagaagcagtcgcagtgaagattgta gatatgaagcgtgccgtagactgtccagaaaatattaagaaagagatctgtatcaataaa atgctaaatcatgaaaatgtagtaaaattctatggtcacaggagagaaggcaatatccaa tatttatttctggagtactgtagtggaggagagctttttgacagaatagagccagacata ggcatgcctgaaccagatgctcagagattcttccatcaactcatggcaggggtggtttat ctgcatggtattggaataactcacagggatattaaaccagaaaatcttctgttggatgaa agggataacctcaaaatctcagactttggcttggcaacagtatttcggtataataatcgt gagcgtttgttgaacaagatgtgtggtactttaccatatgttgctccagaacttctgaag agaagagaatttcatgcagaaccagttgatgtttggtcctgtggaatagtacttactgca atgctcgctggagaattgccatgggaccaacccagtgacagctgtcaggagtattctgac tggaaagaaaaaaaaacatacctcaacccttggaaaaaaatcgattctgctcctctagct ctgctgcataaaatcttagttgagaatccatcagcaagaattaccattccagacatcaaa aaagatagatggtacaacaaacccctcaagaaaggggcaaaaaggccccgagtcacttca ggtggtgtgtcagagtctcccagtggattttctaagcacattcaatccaatttggacttc tctccagtaaacagtgcttctagtgaagaaaatgtgaagtactccagttctcagccagaa ccccgcacaggtctttccttatgggataccagcccctcatacattgataaattggtacaa gggatcagcttttcccagcccacatgtcctgatcatatgcttttgaatagtcagttactt ggcaccccaggatcctcacagaacccctggcagcggttggtcaaaagaatgacacgattc tttaccaaattggatgcagacaaatcttatcaatgcctgaaagagacttgtgagaagttg ggctatcaatggaagaaaagttgtatgaatcaggttactatatcaacaactgataggaga aacaataaactcattttcaaagtgaatttgttagaaatggatgataaaatattggttgac ttccggctttctaagggtgatggattggagttcaagagacacttcctgaagattaaaggg aagctgattgatattgtgagcagccagaagatttggcttcctgccacatga

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