| Entry |
|
|---|
| Symbol |
CHEK1, CHK1, OZEMA21
|
|---|
| Name |
(RefSeq) checkpoint kinase 1
|
|---|
| KO |
|
|---|
| Organism |
|
|---|
| Pathway |
| hsa05166 | Human T-cell leukemia virus 1 infection |
| hsa05170 | Human immunodeficiency virus 1 infection |
|
|---|
| Network |
nt06160 Human T-cell leukemia virus 1 (HTLV-1) nt06161 Human immunodeficiency virus 1 (HIV-1) nt06230 Cell cycle (cancer) nt06506 Double-strand break repair |
|---|
| Element |
| N00456 | HIV Vpr to CDC25-cell cycle G2M |
| N00499 | ATR-p21-Cell cycle G2/M |
| N00500 | HTLV-1 Tax to p21-cell cycle G2/M |
|
|---|
| Disease |
| H01897 | Oocyte/zygote/embryo maturation arrest |
|
|---|
| Drug target |
|
|---|
| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09160 Human Diseases
09161 Cancer: overview
05203 Viral carcinogenesis
1111 (CHEK1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
1111 (CHEK1)
05170 Human immunodeficiency virus 1 infection
1111 (CHEK1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
1111 (CHEK1)
09182 Protein families: genetic information processing
03400 DNA repair and recombination proteins [BR:hsa03400]
1111 (CHEK1)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
1111 (CHEK1)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: CAMK group
CAMKL family
1111 (CHEK1)
DNA repair and recombination proteins [BR:hsa03400]
Eukaryotic type
Check point factors
Other check point factors
1111 (CHEK1)
|
|---|
| SSDB |
|
|---|
| Motif |
|
|---|
| Other DBs |
|
|---|
| Structure |
|
|---|
| LinkDB |
|
|---|
| Position |
11:125625136..125681124
|
|---|
| AA seq |
476 aa
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT |
|---|
| NT seq |
1431 nt +upstreamnt +downstreamnt
atggcagtgccctttgtggaagactgggacttggtgcaaaccctgggagaaggtgcctat
ggagaagttcaacttgctgtgaatagagtaactgaagaagcagtcgcagtgaagattgta
gatatgaagcgtgccgtagactgtccagaaaatattaagaaagagatctgtatcaataaa
atgctaaatcatgaaaatgtagtaaaattctatggtcacaggagagaaggcaatatccaa
tatttatttctggagtactgtagtggaggagagctttttgacagaatagagccagacata
ggcatgcctgaaccagatgctcagagattcttccatcaactcatggcaggggtggtttat
ctgcatggtattggaataactcacagggatattaaaccagaaaatcttctgttggatgaa
agggataacctcaaaatctcagactttggcttggcaacagtatttcggtataataatcgt
gagcgtttgttgaacaagatgtgtggtactttaccatatgttgctccagaacttctgaag
agaagagaatttcatgcagaaccagttgatgtttggtcctgtggaatagtacttactgca
atgctcgctggagaattgccatgggaccaacccagtgacagctgtcaggagtattctgac
tggaaagaaaaaaaaacatacctcaacccttggaaaaaaatcgattctgctcctctagct
ctgctgcataaaatcttagttgagaatccatcagcaagaattaccattccagacatcaaa
aaagatagatggtacaacaaacccctcaagaaaggggcaaaaaggccccgagtcacttca
ggtggtgtgtcagagtctcccagtggattttctaagcacattcaatccaatttggacttc
tctccagtaaacagtgcttctagtgaagaaaatgtgaagtactccagttctcagccagaa
ccccgcacaggtctttccttatgggataccagcccctcatacattgataaattggtacaa
gggatcagcttttcccagcccacatgtcctgatcatatgcttttgaatagtcagttactt
ggcaccccaggatcctcacagaacccctggcagcggttggtcaaaagaatgacacgattc
tttaccaaattggatgcagacaaatcttatcaatgcctgaaagagacttgtgagaagttg
ggctatcaatggaagaaaagttgtatgaatcaggttactatatcaacaactgataggaga
aacaataaactcattttcaaagtgaatttgttagaaatggatgataaaatattggttgac
ttccggctttctaagggtgatggattggagttcaagagacacttcctgaagattaaaggg
aagctgattgatattgtgagcagccagaagatttggcttcctgccacatga |
|---|
