KEGG   NETWORK: N00471
Entry
N00471                      Network                                

Name
EBV LMP2A/2B to IFN signaling pathway
Definition
(LMP2A,LMP2B) -| (IFNAR1+IFNAR2)
  Expanded
(K19460,K23074) -| (3454+3455)
Class
nt06122 IFN signaling (viruses)
nt06165 Epstein-Barr virus (EBV)
Type
Pathogen
Pathway
hsa05169  Epstein-Barr virus infection
Disease
H00008  Burkitt lymphoma
H00007  Hodgkin lymphoma
H00054  Nasopharyngeal cancer
Gene
3454  IFNAR1; interferon alpha and beta receptor subunit 1
3455  IFNAR2; interferon alpha and beta receptor subunit 2
Perturbant
K19460 (LMP2A)  LMP2A; EBV latent membrane protein 2A
K23074 (LMP2B)  LMP2B; EBV latent membrane protein 2B
Reference
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
  Authors
Shah KM, Stewart SE, Wei W, Woodman CB, O'Neil JD, Dawson CW, Young LS
  Title
The EBV-encoded latent membrane proteins, LMP2A and LMP2B, limit the actions of interferon by targeting interferon receptors for degradation.
  Journal
Oncogene 28:3903-14 (2009)
DOI:10.1038/onc.2009.249
Reference
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
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