Entry |
|
Name |
HTLV-1 Tax to EGFR-PI3K-NFKB signaling pathway
|
Definition |
TAX -> PI3K -> PIP3 -> AKT -> IKK -> NFKBIA -> NFKB |
Expanded |
K21857 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> (1147+3551+8517) -> 4792 -> (4790+5970) |
Class |
|
Type |
Pathogen
|
Pathway |
hsa05166 | Human T-cell leukemia virus 1 infection |
|
Disease |
|
Gene |
5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
207 | AKT1; AKT serine/threonine kinase 1 |
208 | AKT2; AKT serine/threonine kinase 2 |
10000 | AKT3; AKT serine/threonine kinase 3 |
1147 | CHUK; conserved helix-loop-helix ubiquitous kinase |
3551 | IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta |
8517 | IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma |
4792 | NFKBIA; NFKB inhibitor alpha |
4790 | NFKB1; nuclear factor kappa B subunit 1 |
5970 | RELA; RELA proto-oncogene, NF-kB subunit |
|
Perturbant |
K21857 (TAX) | tax; HTLV protein Tax-1 |
|
Metabolite |
C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
Reference |
|
Authors |
Saggioro D |
Title |
Anti-apoptotic effect of Tax: an NF-kappaB path or a CREB way? |
Journal |
|
Reference |
|
Authors |
Matsuoka M, Jeang KT |
Title |
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation. |
Journal |
|
LinkDB |
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