| Entry |
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| Name |
HTLV-1 Tax to EGFR-PI3K-NFKB signaling pathway
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| Definition |
TAX -> PI3K -> PIP3 -> AKT -> IKK -> NFKBIA -> NFKB |
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| Expanded |
K21857 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> (1147+3551+8517) -> 4792 -> (4790+5970) |
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| Class |
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| Type |
Pathogen
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| Pathway |
| hsa05166 | Human T-cell leukemia virus 1 infection |
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| Disease |
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| Gene |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
| 1147 | CHUK; conserved helix-loop-helix ubiquitous kinase |
| 3551 | IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta |
| 8517 | IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma |
| 4792 | NFKBIA; NFKB inhibitor alpha |
| 4790 | NFKB1; nuclear factor kappa B subunit 1 |
| 5970 | RELA; RELA proto-oncogene, NF-kB subunit |
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| Perturbant |
| K21857 (TAX) | tax; HTLV protein Tax-1 |
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| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
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| Reference |
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| Authors |
Saggioro D |
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| Title |
Anti-apoptotic effect of Tax: an NF-kappaB path or a CREB way? |
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| Journal |
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| Reference |
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| Authors |
Matsuoka M, Jeang KT |
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| Title |
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation. |
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| Journal |
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| LinkDB |
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