| Entry |
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| Name |
HTLV-1 Tax to TNF-JNK signaling pathway
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| Definition |
TAX -> (MAPK8,MAPK9,MAPK10) -> JUN => MMP7 |
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| Expanded |
K21857 -> (5599,5601,5602) -> 3725 => 4316 |
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| Class |
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| Type |
Pathogen
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| Pathway |
| hsa05166 | Human T-cell leukemia virus 1 infection |
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| Disease |
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| Gene |
| 5599 | MAPK8; mitogen-activated protein kinase 8 |
| 5601 | MAPK9; mitogen-activated protein kinase 9 |
| 5602 | MAPK10; mitogen-activated protein kinase 10 |
| 3725 | JUN; Jun proto-oncogene, AP-1 transcription factor subunit |
| 4316 | MMP7; matrix metallopeptidase 7 |
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| Perturbant |
| K21857 (TAX) | tax; HTLV protein Tax-1 |
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| Reference |
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| Authors |
Geleziunas R, Ferrell S, Lin X, Mu Y, Cunningham ET Jr, Grant M, Connelly MA, Hambor JE, Marcu KB, Greene WC |
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| Title |
Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases. |
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| Journal |
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| Reference |
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| Authors |
Nakachi S, Nakazato T, Ishikawa C, Kimura R, Mann DA, Senba M, Masuzaki H, Mori N |
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| Title |
Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling. |
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| Journal |
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| LinkDB |
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