KEGG   NETWORK: N00523
Entry
N00523                      Network                                
Name
HCV Core to p21-cell cycle G1/S
Definition
Core -| CDKN1A
  Expanded
K22271 -| 1026
Class
nt06263 Hepatocellular carcinoma
nt06163 Hepatitis C virus (HCV)
Type
Pathogen
Pathway
hsa05160  Hepatitis C
Disease
H00048  Hepatocellular carcinoma
Gene
1026  CDKN1A; cyclin dependent kinase inhibitor 1A
Perturbant
K22271 (Core)  Core; HCV core protein
Reference
PMID:12056797
  Authors
Yamanaka T, Uchida M, Doi T
  Title
Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein.
  Journal
Biochem Biophys Res Commun 294:521-7 (2002)
DOI:10.1016/S0006-291X(02)00507-7
Reference
  Authors
Tran G.
  Title
The role of hepatitis C virus in the pathogenesis of hepatocellular carcinoma
  Journal
Biosci Horiz 1:167-175 (2008)
DOI:10.1093/biohorizons/hzn020
Reference
PMID:23577194
  Authors
Shiu TY, Huang SM, Shih YL, Chu HC, Chang WK, Hsieh TY
  Title
Hepatitis C virus core protein down-regulates p21(Waf1/Cip1) and inhibits curcumin-induced apoptosis through microRNA-345 targeting in human hepatoma cells.
  Journal
PLoS One 8:e61089 (2013)
DOI:10.1371/journal.pone.0061089
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