Entry Name HBV pol to TLR3-IRF3 signaling pathway
Definition P -| DDX3X == (IKBKE+TBK1)
Expanded K21037 -| 1654 == (9641+29110)
Class Type Pathogen
Pathway Disease H00048 Hepatocellular carcinoma
Gene 1654 DDX3X; DEAD-box helicase 3 X-linked
9641 IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon
29110 TBK1; TANK binding kinase 1
Perturbant K21037 (P) P; Hepadnavirus DNA polymerase / reverse transcriptase / RNase H
Reference Authors Yu S, Chen J, Wu M, Chen H, Kato N, Yuan Z
Title Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3.
Journal Reference Authors Revill P, Yuan Z
Title New insights into how HBV manipulates the innate immune response to establish acute and persistent infection.
Journal Reference Authors Ariumi Y
Title Multiple functions of DDX3 RNA helicase in gene regulation, tumorigenesis, and viral infection.
Journal LinkDB All DBs
