KEGG   Homo sapiens (human): 1654
Entry
1654              CDS       T01001                                 
Symbol
DDX3X, CAP-Rf, DBX, DDX14, DDX3, HLP2, MRX102, MRXSSB
Name
(RefSeq) DEAD-box helicase 3 X-linked
  KO
K11594  ATP-dependent RNA helicase DDX3X [EC:3.6.4.13]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04622  RIG-I-like receptor signaling pathway
hsa05161  Hepatitis B
hsa05203  Viral carcinogenesis
Network
nt06121  TLR signaling (viruses and bacteria)
nt06162  Hepatitis B virus (HBV)
nt06263  Hepatocellular carcinoma
  Element
N00552  HBV pol to TLR3-IRF3 signaling pathway
Disease
H00480  X-linked mental retardation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04622 RIG-I-like receptor signaling pathway
    1654 (DDX3X)
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    1654 (DDX3X)
  09172 Infectious disease: viral
   05161 Hepatitis B
    1654 (DDX3X)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    1654 (DDX3X)
   03041 Spliceosome [BR:hsa03041]
    1654 (DDX3X)
   03036 Chromosome and associated proteins [BR:hsa03036]
    1654 (DDX3X)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.4  Acting on acid anhydrides to facilitate cellular and subcellular movement
    3.6.4.13  RNA helicase
     1654 (DDX3X)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Transport factors
    eIF4F and regulatory proteins
     1654 (DDX3X)
   mRNA cycle factors
    Common to processing body (P body) and stress granule
     1654 (DDX3X)
Spliceosome [BR:hsa03041]
 Other splicing related proteins
  Spliceosome associated proteins (SAPs)
   RNA helicase-like proteins
    1654 (DDX3X)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Gene silencing
   RISC (RNA-induced silencing complex)
    1654 (DDX3X)
SSDB
Motif
Pfam: DEAD Helicase_C ResIII UTP25
Other DBs
NCBI-GeneID: 1654
NCBI-ProteinID: NP_001347
OMIM: 300160
HGNC: 2745
Ensembl: ENSG00000215301
Vega: OTTHUMG00000021369
Pharos: O00571(Tchem)
UniProt: O00571
Structure
LinkDB
Position
X:41333308..41364472
AA seq 662 aa
MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGW
SSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFE
RGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIE
SFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILS
QIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVV
YGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQ
IRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVV
WVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDR
EEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGL
ATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGAR
DYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWW
GN
NT seq 1989 nt   +upstreamnt  +downstreamnt
atgagtcatgtggcagtggaaaatgcgctcgggctggaccagcagtttgctggcctagac
ctgaactcttcagataatcagagtggaggaagtacagccagcaaagggcgctatattcct
cctcatttaaggaaccgagaagctactaaaggtttctacgataaagacagttcagggtgg
agttctagcaaagataaggatgcgtatagcagttttggatctcgtagtgattcaagaggg
aagtctagcttcttcagtgatcgtggaagtggatcaaggggaaggtttgatgatcgtgga
cggagtgattacgatggcattggcagccgtggtgacagaagtggctttggcaaatttgaa
cgtggtggaaacagtcgctggtgtgacaaatcagatgaagatgattggtcaaaaccactc
ccaccaagtgaacgcttggaacaggaactcttttctggaggcaacactgggattaatttt
gagaaatacgatgacattccagttgaggcaacaggcaacaactgtcctccacatattgaa
agtttcagtgatgttgagatgggagaaattatcatgggaaacattgagcttactcgttat
actcgcccaactccagtgcaaaagcatgctattcctattatcaaagagaaaagagacttg
atggcttgtgcccaaacagggtctggaaaaactgcagcatttctgttgcccatcttgagt
cagatttattcagatggtccaggcgaggctttgagggccatgaaggaaaatggaaggtat
gggcgccgcaaacaatacccaatctccttggtattagcaccaacgagagagttggcagta
cagatctacgaggaagccagaaaattttcataccgatctagagttcgtccttgcgtggtt
tatggtggtgccgatattggtcagcagattcgagacttggaacgtggatgccatttgtta
gtagccactccaggacgtctagtggatatgatggaaagaggaaagattggattagacttt
tgcaaatacttggtgttagatgaagctgatcggatgttggatatggggtttgagcctcag
attcgtagaatagtcgaacaagatactatgcctccaaagggtgtccgccacactatgatg
tttagtgctacttttcctaaggaaatacagatgctggctcgtgatttcttagatgaatat
atcttcttggctgtaggaagagttggctctacctctgaaaacatcacacagaaagtagtt
tgggtggaagaatcagacaaacggtcatttctgcttgacctcctaaatgcaacaggcaag
gattcactgaccttagtgtttgtggagaccaaaaagggtgcagattctctggaggatttc
ttataccatgaaggatacgcatgtaccagcatccatggagaccgttctcagagggataga
gaagaggcccttcaccagttccgctcaggaaaaagcccaattttagtggctacagcagta
gcagcaagaggactggacatttcaaatgtgaaacatgttatcaattttgacttgccaagt
gatattgaagaatatgtacatcgtattggtcgtacgggacgtgtaggaaaccttggcctg
gcaacctcattctttaacgagaggaacataaatattactaaggatttgttggatcttctt
gttgaagctaaacaagaagtgccgtcttggttagaaaacatggcttatgaacaccactac
aagggtagcagtcgtggacgttctaagagtagcagatttagtggagggtttggtgccaga
gactaccgacaaagtagcggtgccagcagttccagcttcagcagcagccgcgcaagcagc
agccgcagtggcggaggtggccacggtagcagcagaggatttggtggaggtggctatgga
ggcttttacaacagtgatggatatggaggaaattataactcccagggggttgactggtgg
ggtaactga

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