KEGG   NETWORK: N00683
Entry
N00683                      Network                                
Name
CD80/CD86-CD28-PI3K signaling pathway
Definition
(CD80,CD86) -> CD28 -> PI3K -> PIP3 -> AKT -| GSK3B
  Expanded
(941,942) -> 940 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 2932
Class
nt06537 TCR/BCR signaling
nt06169 Measles virus (MV)
Type
Reference
Pathway
hsa04660  T cell receptor signaling pathway
Gene
941  CD80; CD80 molecule
942  CD86; CD86 molecule
940  CD28; CD28 molecule
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2932  GSK3B; glycogen synthase kinase 3 beta
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27192564
  Authors
Esensten JH, Helou YA, Chopra G, Weiss A, Bluestone JA
  Title
CD28 Costimulation: From Mechanism to Therapy.
  Journal
Immunity 44:973-88 (2016)
DOI:10.1016/j.immuni.2016.04.020
Reference
PMID:12195013
  Authors
Diehn M, Alizadeh AA, Rando OJ, Liu CL, Stankunas K, Botstein D, Crabtree GR, Brown PO
  Title
Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation.
  Journal
Proc Natl Acad Sci U S A 99:11796-801 (2002)
DOI:10.1073/pnas.092284399
Reference
PMID:27471717
  Authors
Beyersdorf N, Kerkau T, Hunig T
  Title
CD28 co-stimulation in T-cell homeostasis: a recent perspective.
  Journal
Immunotargets Ther 4:111-22 (2015)
DOI:10.2147/ITT.S61647
Reference
PMID:21487479
  Authors
Riha P, Rudd CE
  Title
CD28 co-signaling in the adaptive immune response.
  Journal
Self Nonself 1:231-240 (2010)
DOI:10.4161/self.1.3.12968
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