KEGG   NETWORK: N00744
Entry
N00744                      Network                                
Name
IAV HA to ERK signaling pathway
Definition
HA -> PRKCA -> RAF
  Expanded
K19251 -> 5578 -> (369,673,5894)
Class
nt06170 Influenza A virus (IAV)
Type
Pathogen
Pathway
hsa05164  Influenza A
Disease
H00398  Influenza
Gene
5578  PRKCA; protein kinase C alpha
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
Perturbant
K19251 (HA)  HA; Influenza A virus hemagglutinin
Reference
PMID:21253874
  Authors
Dai X, Zhang L, Hong T
  Title
Host cellular signaling induced by influenza virus.
  Journal
Sci China Life Sci 54:68-74 (2011)
DOI:10.1007/s11427-010-4116-z
Reference
PMID:19782761
  Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
  Title
Interplay between influenza A virus and the innate immune signaling.
  Journal
Microbes Infect 12:81-7 (2010)
DOI:10.1016/j.micinf.2009.09.007
Reference
PMID:16608852
  Authors
Marjuki H, Alam MI, Ehrhardt C, Wagner R, Planz O, Klenk HD, Ludwig S, Pleschka S
  Title
Membrane accumulation of influenza A virus hemagglutinin triggers nuclear export of the viral genome via protein kinase Calpha-mediated activation of ERK signaling.
  Journal
J Biol Chem 281:16707-15 (2006)
DOI:10.1074/jbc.M510233200
Reference
PMID:18053252
  Authors
Marjuki H, Yen HL, Franks J, Webster RG, Pleschka S, Hoffmann E
  Title
Higher polymerase activity of a human influenza virus enhances activation of the hemagglutinin-induced Raf/MEK/ERK signal cascade.
  Journal
Virol J 4:134 (2007)
DOI:10.1186/1743-422X-4-134
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