Homo sapiens (human): 369
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Entry
369 CDS
T01001
Symbol
ARAF, A-RAF, ARAF1, PKS2, RAFA1
Name
(RefSeq) A-Raf proto-oncogene, serine/threonine kinase
KO
K08845
A-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa01522
Endocrine resistance
hsa04010
MAPK signaling pathway
hsa04012
ErbB signaling pathway
hsa04068
FoxO signaling pathway
hsa04270
Vascular smooth muscle contraction
hsa04650
Natural killer cell mediated cytotoxicity
hsa04720
Long-term potentiation
hsa04726
Serotonergic synapse
hsa04730
Long-term depression
hsa04810
Regulation of actin cytoskeleton
hsa04910
Insulin signaling pathway
hsa04914
Progesterone-mediated oocyte maturation
hsa04928
Parathyroid hormone synthesis, secretion and action
hsa05010
Alzheimer disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05034
Alcoholism
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05200
Pathways in cancer
hsa05205
Proteoglycans in cancer
hsa05208
Chemical carcinogenesis - reactive oxygen species
hsa05210
Colorectal cancer
hsa05211
Renal cell carcinoma
hsa05212
Pancreatic cancer
hsa05213
Endometrial cancer
hsa05214
Glioma
hsa05215
Prostate cancer
hsa05218
Melanoma
hsa05219
Bladder cancer
hsa05220
Chronic myeloid leukemia
hsa05221
Acute myeloid leukemia
hsa05223
Non-small cell lung cancer
hsa05224
Breast cancer
hsa05225
Hepatocellular carcinoma
hsa05226
Gastric cancer
Network
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06166
Human papillomavirus (HPV)
nt06167
Human cytomegalovirus (HCMV)
nt06170
Influenza A virus (IAV)
nt06181
Salmonella
nt06210
ERK signaling (cancer)
nt06220
Calcium signaling (cancer)
nt06260
Colorectal cancer
nt06261
Gastric cancer
nt06262
Pancreatic cancer
nt06263
Hepatocellular carcinoma
nt06264
Renal cell carcinoma
nt06265
Bladder cancer
nt06266
Non-small cell lung cancer
nt06268
Melanoma
nt06270
Breast cancer
nt06271
Endometrial cancer
nt06273
Glioma
nt06274
Thyroid cancer
nt06275
Acute myeloid leukemia
nt06276
Chronic myeloid leukemia
nt06324
GHRH-GH-IGF signaling
nt06460
Alzheimer disease
nt06466
Pathways of neurodegeneration
nt06526
MAPK signaling
Element
N00001
EGF-EGFR-RAS-ERK signaling pathway
N00002
BCR-ABL fusion kinase to RAS-ERK signaling pathway
N00003
Mutation-activated KIT to RAS-ERK signaling pathway
N00004
Duplication or mutation-activated FLT3 to RAS-ERK signaling pathway
N00005
Mutation-activated MET to RAS-ERK signaling pathway
N00006
Amplified EGFR to RAS-ERK signaling pathway
N00007
EML4-ALK fusion kinase to RAS-ERK signaling pathway
N00008
RET fusion kinase to RAS-ERK signaling pathway
N00009
TRK fusion kinase to RAS-ERK signaling pathway
N00011
Mutation-activated FGFR3 to RAS-ERK signaling pathway
N00012
Mutation-activated KRAS/NRAS to ERK signaling pathway
N00014
Mutation-activated EGFR to RAS-ERK signaling pathway
N00015
PDGF-PDGFR-RAS-ERK signaling pathway
N00016
PDGF-overexpression to RAS-ERK signaling pathway
N00018
Amplified PDGFR to RAS-ERK signaling pathway
N00019
FGF-FGFR-RAS-ERK signaling pathway
N00020
Amplified FGFR to RAS-ERK signaling pathway
N00021
EGF-ERBB2-RAS-ERK signaling pathway
N00022
ERBB2-overexpression to RAS-ERK signaling pathway
N00023
EGF-EGFR-PLCG-ERK signaling pathway
N00024
Mutation-activated EGFR to PLCG-ERK signaling pathway
N00025
EML4-ALK fusion kinase to PLCG-ERK signaling pathway
N00041
EGFR-overexpression to RAS-ERK signaling pathway
N00077
HRAS-overexpression to ERK signaling pathway
N00078
Mutation-activated HRAS to ERK signaling pathway
N00215
KITLG-KIT-RAS-ERK signaling pathway
N00216
HGF-MET-RAS-ERK signaling pathway
N00217
FLT3LG-FLT3-RAS-ERK signaling pathway
N00229
TGFA-EGFR-RAS-ERK signaling pathway
N00230
TGFA-overexpression to RAS-ERK signaling pathway
N00233
IGF-IGF1R-RAS-ERK signaling pathway
N00235
IGF2-overexpression to RAS-ERK signaling pathway
N00237
IGF1R-overexpression to RAS-ERK signaling pathway
N00246
HGF-overexpression to RAS-ERK signaling pathway
N00248
MET-overexpression to RAS-ERK signaling pathway
N00252
Amplified ERBB2 to RAS-ERK signaling pathway
N00259
Amplified MET to RAS-ERK signaling pathway
N00276
EGF-overexpression to RAS-ERK signaling pathway
N00277
EREG-EGFR-RAS-ERK signaling pathway
N00278
EREG-overexpression to RAS-ERK signaling pathway
N00279
AREG-EGFR-RAS-ERK signaling pathway
N00280
AREG-overexpression to RAS-ERK signaling pathway
N00367
HPV E5 to EGFR-RAS-ERK signaling pathway
N00386
HCMV gB to PDGFR-RAS-ERK signaling pathway
N00513
Mutation-activated EGFR to RAS-ERK signaling pathway
N00518
HCV Core to ERK signaling pathway
N00538
Ca2+-PYK2-RAS-ERK signaling pathway
N00540
HBV HBx to RAS-ERK signaling pathway
N00546
CXCL12-CXCR4-PKC-ERK signaling pathaway
N00744
IAV HA to ERK signaling pathway
N00994
AGE-RAGE signaling pathway
N00996
Mutation-caused aberrant Abeta to AGE-RAGE signaling pathway
N01062
Mutation-activated MET to RAS-ERK signaling pathway
N01064
Mutation-activated RET to RAS-ERK signaling pathway
N01119
RAC/CDC42-PAK-ERK signaling pathway
N01343
ACH-CHRN-RAS-ERK signaling pathway
N01344
NNK/NNN to RAS-ERK signaling pathway
N01351
E2-ER-RAS-ERK signaling pathway
N01352
BPA to RAS-ERK signaling pathway
N01353
E2 to RAS-ERK signaling pathway
N01354
BPA to RAS-ERK signaling pathway
N01360
P4-PR-RAS-ERK signaling pathway
N01361
P4/MPA to PR-RAS-ERK signaling pathway
N01408
Metals to RAS-ERK signaling pathway
N01592
GF-RTK-RAS-ERK signaling pathway
N01598
Regulation of GF-RTK-RAS-ERK signaling, MRAS-SHOC2-PP1 holophosphatase
Disease
H02425
Erdheim-Chester disease
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
369 (ARAF)
04012 ErbB signaling pathway
369 (ARAF)
04068 FoxO signaling pathway
369 (ARAF)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
369 (ARAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
369 (ARAF)
09152 Endocrine system
04910 Insulin signaling pathway
369 (ARAF)
04914 Progesterone-mediated oocyte maturation
369 (ARAF)
04928 Parathyroid hormone synthesis, secretion and action
369 (ARAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
369 (ARAF)
09156 Nervous system
04726 Serotonergic synapse
369 (ARAF)
04720 Long-term potentiation
369 (ARAF)
04730 Long-term depression
369 (ARAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
369 (ARAF)
05205 Proteoglycans in cancer
369 (ARAF)
05208 Chemical carcinogenesis - reactive oxygen species
369 (ARAF)
09162 Cancer: specific types
05210 Colorectal cancer
369 (ARAF)
05212 Pancreatic cancer
369 (ARAF)
05225 Hepatocellular carcinoma
369 (ARAF)
05226 Gastric cancer
369 (ARAF)
05214 Glioma
369 (ARAF)
05221 Acute myeloid leukemia
369 (ARAF)
05220 Chronic myeloid leukemia
369 (ARAF)
05218 Melanoma
369 (ARAF)
05211 Renal cell carcinoma
369 (ARAF)
05219 Bladder cancer
369 (ARAF)
05215 Prostate cancer
369 (ARAF)
05213 Endometrial cancer
369 (ARAF)
05224 Breast cancer
369 (ARAF)
05223 Non-small cell lung cancer
369 (ARAF)
09172 Infectious disease: viral
05161 Hepatitis B
369 (ARAF)
05160 Hepatitis C
369 (ARAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
369 (ARAF)
05022 Pathways of neurodegeneration - multiple diseases
369 (ARAF)
09165 Substance dependence
05034 Alcoholism
369 (ARAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
369 (ARAF)
01522 Endocrine resistance
369 (ARAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
369 (ARAF)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
369 (ARAF)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
369 (ARAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
ABC1
Pkinase_fungal
TUG-UBL1
Kdo
Motif
Other DBs
NCBI-GeneID:
369
NCBI-ProteinID:
NP_001645
OMIM:
311010
HGNC:
646
Ensembl:
ENSG00000078061
UniProt:
P10398
A0A024R178
Structure
PDB
LinkDB
All DBs
Position
X:47561205..47571908
Genome browser
AA seq
606 aa
AA seq
DB search
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL
TPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS
TDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq
1821 nt
NT seq
+upstream
nt +downstream
nt
atggagccaccacggggcccccctgccaatggggccgagccatcccgggcagtgggcacc
gtcaaagtatacctgcccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctgaaggtgcggggtctaaatcaggactgctgtgtg
gtctaccgactcatcaagggacgaaagacggtcactgcctgggacacagccattgctccc
ctggatggcgaggagctcattgtcgaggtccttgaagatgtcccgctgaccatgcacaat
tttgtacggaagaccttcttcagcctggcgttctgtgacttctgccttaagtttctgttc
catggcttccgttgccaaacctgtggctacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgttgacatgagtaccaaccgccaacagttctaccacagtgtccaggat
ttgtccggaggctccagacagcatgaggctccctcgaaccgccccctgaatgagttgcta
accccccagggtcccagcccccgcacccagcactgtgacccggagcacttccccttccct
gccccagccaatgcccccctacagcgcatccgctccacgtccactcccaacgtccatatg
gtcagcaccacggcccccatggactccaacctcatccagctcactggccagagtttcagc
actgatgctgccggtagtagaggaggtagtgatggaaccccccgggggagccccagccca
gccagcgtgtcctcggggaggaagtccccacattccaagtcaccagcagagcagcgcgag
cggaagtccttggccgatgacaagaagaaagtgaagaacctggggtaccgggactcaggc
tattactgggaggtaccacccagtgaggtgcagctgctgaagaggatcgggacgggctcg
tttggcaccgtgtttcgagggcggtggcatggcgatgtggccgtgaaggtgctcaaggtg
tcccagcccacagctgagcaggcccaggctttcaagaatgagatgcaggtgctcaggaag
acgcgacatgtcaacatcttgctgtttatgggcttcatgacccggccgggatttgccatc
atcacacagtggtgtgagggctccagcctctaccatcacctgcatgtggccgacacacgc
ttcgacatggtccagctcatcgacgtggcccggcagactgcccagggcatggactacctc
catgccaagaacatcatccaccgagatctcaagtctaacaacatcttcctacatgagggg
ctcacggtgaagatcggtgactttggcttggccacagtgaagactcgatggagcggggcc
cagcccttggagcagccctcaggatctgtgctgtggatggcagctgaggtgatccgtatg
caggacccgaacccctacagcttccagtcagacgtctatgcctacggggttgtgctctac
gagcttatgactggctcactgccttacagccacattggctgccgtgaccagattatcttt
atggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaactgccccaag
gccatgcggcgcctgctgtctgactgcctcaagttccagcgggaggagcggcccctcttc
ccccagatcctggccacaattgagctgctgcaacggtcactccccaagattgagcggagt
gcctcggaaccctccttgcaccgcacccaggccgatgagttgcctgcctgcctactcagc
gcagcccgccttgtgccttag
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integrated database retrieval system