| Entry |
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| Name |
Mutation-activated LRRK2 to intrinsic apoptotic pathway
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| Definition |
LRRK2* -> CYCS == APAF1 -> CASP9 -> CASP3 |
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| Expanded |
120892v1 -> 54205 == 317 -> 842 -> 836 |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
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| Gene |
| 120892 | LRRK2; leucine rich repeat kinase 2 |
| 54205 | CYCS; cytochrome c, somatic |
| 317 | APAF1; apoptotic peptidase activating factor 1 |
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| Variant |
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| Reference |
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| Authors |
Franco-Iborra S, Vila M, Perier C |
|---|
| Title |
The Parkinson Disease Mitochondrial Hypothesis: Where Are We at? |
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| Journal |
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| Reference |
|
|---|
| Authors |
Bose A, Beal MF |
|---|
| Title |
Mitochondrial dysfunction in Parkinson's disease. |
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| Journal |
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| Reference |
|
|---|
| Authors |
Iaccarino C, Crosio C, Vitale C, Sanna G, Carri MT, Barone P |
|---|
| Title |
Apoptotic mechanisms in mutant LRRK2-mediated cell death. |
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| Journal |
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| LinkDB |
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