Homo sapiens (human): 317
Help
Entry
317 CDS
T01001
Symbol
APAF1, APAF-1, CED4
Name
(RefSeq) apoptotic peptidase activating factor 1
KO
K02084
apoptotic protease-activating factor
Organism
hsa
Homo sapiens (human)
Pathway
hsa01524
Platinum drug resistance
hsa04115
p53 signaling pathway
hsa04210
Apoptosis
hsa04215
Apoptosis - multiple species
hsa05010
Alzheimer disease
hsa05012
Parkinson disease
hsa05014
Amyotrophic lateral sclerosis
hsa05016
Huntington disease
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05134
Legionellosis
hsa05152
Tuberculosis
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05162
Measles
hsa05164
Influenza A
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05200
Pathways in cancer
hsa05222
Small cell lung cancer
hsa05417
Lipid and atherosclerosis
Network
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06166
Human papillomavirus (HPV)
nt06167
Human cytomegalovirus (HCMV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06170
Influenza A virus (IAV)
nt06231
Apoptosis (cancer)
nt06260
Colorectal cancer
nt06263
Hepatocellular carcinoma
nt06267
Small cell lung cancer
nt06460
Alzheimer disease
nt06461
Huntington disease
nt06462
Spinocerebellar ataxia
nt06463
Parkinson disease
nt06464
Amyotrophic lateral sclerosis
nt06465
Prion disease
nt06466
Pathways of neurodegeneration
nt06524
Apoptosis
nt06528
Calcium signaling
Element
N00098
Intrinsic apoptotic pathway
N00100
BCL2-overexpression to intrinsic apoptotic pathway
N00146
Crosstalk between extrinsic and intrinsic apoptotic pathways
N00449
HIV Tat/Nef to crosstalk between extrinsic and intrinsic apoptotic pathways
N00478
EBV BARF1 to intrinsic apoptotic pathway
N00967
VGCC-Ca2+ -apoptotic pathway
N00984
mGluR5-Ca2+ -apoptotic pathway
N00985
Mutation-caused aberrant Htt to mGluR5-Ca2+ -apoptotic pathway
N00987
Mutation-caused aberrant Htt to transport of calcium
N01002
Mutation-caused aberrant Abeta to mGluR5-Ca2+ -apoptotic pathway
N01005
Mutation-caused aberrant Abeta to crosstalk between extrinsic and intrinsic apoptotic pathways
N01007
Mutation-caused aberrant PSEN to mGluR5-Ca2+ -apoptotic pathway
N01031
Mutation-caused aberrant SNCA to VGCC-Ca2+ -apoptotic pathway
N01047
Mutation-activated LRRK2 to intrinsic apoptotic pathway
N01048
Mutation-inactivated PINK1 to intrinsic apoptotic pathway
N01049
Mutation-inactivated PRKN to intrinsic apoptotic pathway
N01050
Mutation-inactivated PINK1 to intrinsic apoptotic pathway
N01135
Mutation-caused aberrant SOD1 to intrinsic apoptotic pathway
N01199
Scrapie conformation PrPSc to mGluR5-Ca2+ -apoptotic pathway
N01200
Scrapie conformation PrPSc to transport of calcium
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
317 (APAF1)
04215 Apoptosis - multiple species
317 (APAF1)
04115 p53 signaling pathway
317 (APAF1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
317 (APAF1)
09162 Cancer: specific types
05222 Small cell lung cancer
317 (APAF1)
09172 Infectious disease: viral
05161 Hepatitis B
317 (APAF1)
05160 Hepatitis C
317 (APAF1)
05164 Influenza A
317 (APAF1)
05162 Measles
317 (APAF1)
05168 Herpes simplex virus 1 infection
317 (APAF1)
05169 Epstein-Barr virus infection
317 (APAF1)
09171 Infectious disease: bacterial
05134 Legionellosis
317 (APAF1)
05152 Tuberculosis
317 (APAF1)
09164 Neurodegenerative disease
05010 Alzheimer disease
317 (APAF1)
05012 Parkinson disease
317 (APAF1)
05014 Amyotrophic lateral sclerosis
317 (APAF1)
05016 Huntington disease
317 (APAF1)
05020 Prion disease
317 (APAF1)
05022 Pathways of neurodegeneration - multiple diseases
317 (APAF1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
317 (APAF1)
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
317 (APAF1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
WD40
NB-ARC
WD40_WDHD1_1st
WD40_Prp19
APAF1_C
WD40_CDC20-Fz
Beta-prop_EML_2
EIF3I
Beta-prop_TEP1_2nd
WDR55
APAF-1-like_WHD
WD40_MABP1-WDR62_2nd
Beta-prop_CAF1B_HIR1
Beta-prop_WDR90_POC16_2nd
ANAPC4_WD40
Beta-prop_EML
Beta-prop_WDR75_1st
Beta-prop_IFT122_1st
WDR90_beta-prop_4th
CARD
Beta-prop_RIG_2nd
NBCH_WD40
Beta-prop_EIPR1
Beta-prop_WDR19_1st
Beta-prop_TEP1_C
Beta-prop_Vps41
WD40_MABP1-WDR62_1st
Beta-prop_SCAP
RMC1_N
Beta-prop_IFT140_1st
Beta-prop_HPS5
Beta-prop_WDR35_TULP_N
eIF2A
WD40_like
Beta-prop_NUP159_NUP214
Beta-prop_WDR11_2nd
CARD_2
WD40_RFWD3
Ge1_WD40
Beta-prop_DCAF4
Beta-prop_VPS8
Utp8_b_propeller
Beta-prop_Nup120_160
AAA_16
Beta-prop_SPT8
NPHP3_N
AAA_22
NACHT
AAA_18
Motif
Other DBs
NCBI-GeneID:
317
NCBI-ProteinID:
NP_863651
OMIM:
602233
HGNC:
576
Ensembl:
ENSG00000120868
UniProt:
O14727
Structure
PDB
PDBj
LinkDB
All DBs
Position
12:98645290..98735433
Genome browser
AA seq
1248 aa
AA seq
DB search
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP
QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL
ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN
MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD
YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN
KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC
MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV
SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK
KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV
LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS
SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS
INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH
STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS
SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT
EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS
SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD
FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST
LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK
WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
NT seq
3747 nt
NT seq
+upstream
nt +downstream
nt
atggatgcaaaagctcgaaattgtttgcttcaacatagagaagctctggaaaaggacatc
aagacatcctacatcatggatcacatgattagtgatggatttttaacaatatcagaagag
gaaaaagtaagaaatgagcccactcaacagcaaagagcagctatgctgattaaaatgata
cttaaaaaagataatgattcctacgtatcattctacaatgctctactacatgaaggatat
aaagatcttgctgcccttctccatgatggcattcctgttgtctcttcttccagtggtaaa
gattcagttagtggaataacttcgtatgtaaggacagtcctgtgtgaaggtggagtacca
cagaggccagttgtttttgtcacaaggaagaagctggtgaatgcaattcagcagaagctc
tccaaattgaaaggtgaaccaggatgggtcaccatacatggaatggcaggctgtgggaag
tctgtattagctgcagaagctgttagagatcattcccttttagaaggttgtttcccaggg
ggagtgcattgggtttcagttgggaaacaagacaaatctgggcttctgatgaaactgcag
aatctttgcacacggttggatcaggatgagagtttttcccagaggcttccacttaatatt
gaagaggctaaagaccgtctccgcattctgatgcttcgcaaacacccaaggtctctcttg
atcttggatgatgtttgggactcttgggtgttgaaagcttttgacagtcagtgtcagatt
cttcttacaaccagagacaagagtgttacagattcagtaatgggtcctaaatatgtagtc
cctgtggagagttccttaggaaaggaaaaaggacttgaaattttatccctttttgttaat
atgaagaaggcagatttgccagaacaagctcatagtattataaaagaatgtaaaggctct
ccccttgtagtatctttaattggtgcacttttacgtgattttcccaatcgctgggagtac
tacctcaaacagcttcagaataagcagtttaagagaataaggaaatcttcgtcttatgat
tatgaggctctagatgaagccatgtctataagtgttgaaatgctcagagaagacatcaaa
gattattacacagatctttccatccttcagaaggacgttaaggtgcctacaaaggtgtta
tgtattctctgggacatggaaactgaagaagttgaagacatactgcaggagtttgtaaat
aagtctcttttattctgtgatcggaatggaaagtcgtttcgttattatttacatgatctt
caagtagattttcttacagagaagaattgcagccagcttcaggatctacataagaagata
atcactcagtttcagagatatcaccagccgcatactctttcaccagatcaggaagactgt
atgtattggtacaactttctggcctatcacatggccagtgccaagatgcacaaggaactt
tgtgctttaatgttttccctggattggattaaagcaaaaacagaacttgtaggccctgct
catctgattcatgaatttgtggaatacagacatatactagatgaaaaggattgtgcagtc
agtgagaattttcaggagtttttatctttaaatggacaccttcttggacgacagccattt
cctaatattgtacaactgggtctctgtgagccggaaacttcagaagtttatcagcaagct
aagctgcaggccaagcaggaggtcgataatggaatgctttacctggaatggataaacaaa
aaaaacatcacgaatctttcccgcttagttgtccgcccccacacagatgctgtttaccat
gcctgcttttctgaggatggtcagagaatagcttcttgtggagctgataaaaccttacag
gtgttcaaagctgaaacaggagagaaacttctagaaatcaaggctcatgaggatgaagtg
ctttgttgtgcattctctacagatgacagatttatagcaacctgctcagtggataaaaaa
gtgaagatttggaattctatgactggggaactagtacacacctatgatgagcactcagag
caagtcaattgctgccatttcaccaacagtagtcatcatcttctcttagccactgggtca
agtgactgcttcctcaaactttgggatttgaatcaaaaagaatgtcgaaataccatgttt
ggtcatacaaattcagtcaatcactgcagattttcaccagatgataagcttttggctagt
tgttcagctgatggaaccttaaagctttgggatgcgacatcagcaaatgagaggaaaagc
attaatgtgaaacagttcttcctaaatttggaggaccctcaagaggatatggaagtgata
gtgaagtgttgttcgtggtctgctgatggtgcaaggataatggtggcagcaaaaaataaa
atctttctttttgacattcatactagtggcctattgggagaaatccacacgggccatcac
agcaccatccagtactgtgacttctccccacaaaaccatttggcagtggttgctttgtcc
cagtactgtgtagagttgtggaatacagactcacgttcaaaggtggctgattgcagagga
catttaagttgggttcatggtgtgatgttttctcctgatggatcatcatttttgacatct
tctgatgaccagacaatcaggctctgggagacaaagaaagtatgtaagaactctgctgta
atgttaaagcaagaagtagatgttgtgtttcaagaaaatgaagtgatggtccttgcagtt
gaccatataagacgtctgcaactcattaatggaagaacaggtcagattgattatctgact
gaagctcaagttagctgctgttgcttaagtccacatcttcagtacattgcatttggagat
gaaaatggagccattgagattttagaacttgtaaacaatagaatcttccagtccaggttt
cagcacaagaaaactgtatggcacatccagttcacagccgatgagaagactcttatttca
agttctgatgatgctgaaattcaggtatggaattggcaattggacaaatgtatctttcta
cgaggccatcaggaaacagtgaaagactttagactcttgaaaaattcaagactgctttct
tggtcatttgatggaacagtgaaggtatggaatattattactggaaataaagaaaaagac
tttgtctgtcaccagggtacagtactttcttgtgacatttctcacgatgctaccaagttt
tcatctacctctgctgacaagactgcaaagatctggagttttgatctccttttgccactt
catgaattgaggggccacaacggctgtgtgcgctgctctgccttctctgtggacagtacc
ctgctggcaacgggagatgacaatggagaaatcaggatatggaatgtctcaaacggtgag
cttcttcatttgtgtgctccgctttcagaagaaggagctgctacccatggaggctgggtg
actgacctttgcttttctccagatggcaaaatgcttatctctgctggaggatatattaag
tggtggaacgttgtcactggggaatcctcacagaccttctacacaaatggaaccaatctt
aagaaaatacacgtgtcccctgacttcaaaacatatgtgactgtggataatcttggtatt
ttatatattttacagactttagaataa
DBGET
integrated database retrieval system
