KEGG   Homo sapiens (human): 842
Entry
842               CDS       T01001                                 
Symbol
CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56
Name
(RefSeq) caspase 9
  KO
K04399  caspase 9 [EC:3.4.22.62]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01524  Platinum drug resistance
hsa04115  p53 signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04210  Apoptosis
hsa04215  Apoptosis - multiple species
hsa04370  VEGF signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05130  Pathogenic Escherichia coli infection
hsa05134  Legionellosis
hsa05145  Toxoplasmosis
hsa05152  Tuberculosis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05210  Colorectal cancer
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05215  Prostate cancer
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05416  Viral myocarditis
hsa05417  Lipid and atherosclerosis
Network
nt06131  Apoptosis (viruses and bacteria)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06170  Influenza A virus (IAV)
nt06231  Apoptosis
nt06260  Colorectal cancer
nt06263  Hepatocellular carcinoma
nt06267  Small cell lung cancer
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06462  Spinocerebellar ataxia
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06524  Apoptosis
nt06528  Calcium signaling
  Element
N00098  Intrinsic apoptotic pathway
N00100  BCL2-overexpression to intrinsic apoptotic pathway
N00101  DCC-apoptotic pathway
N00102  Loss of DCC to DCC-apoptotic pathway
N00146  Crosstalk between extrinsic and intrinsic apoptotic pathways
N00449  HIV Tat/Nef to crosstalk between extrinsic and intrinsic apoptotic pathways
N00478  EBV BARF1 to intrinsic apoptotic pathway
N00533  HBV HBx to Crosstalk between extrinsic and intrinsic apoptotic pathways
N00939  Escherichia EspF to intrinsic apoptotic pathway
N00967  VGCC-Ca2+ -apoptotic pathway
N00984  mGluR5-Ca2+ -apoptotic pathway
N00985  Mutation-caused aberrant Htt to mGluR5-Ca2+ -apoptotic pathway
N00987  Mutation-caused aberrant Htt to transport of calcium
N01002  Mutation-caused aberrant Abeta to mGluR5-Ca2+ -apoptotic pathway
N01005  Mutation-caused aberrant Abeta to crosstalk between extrinsic and intrinsic apoptotic pathways
N01007  Mutation-caused aberrant PSEN to mGluR5-Ca2+ -apoptotic pathway
N01031  Mutation-caused aberrant SNCA to VGCC-Ca2+ -apoptotic pathway
N01047  Mutation-activated LRRK2 to intrinsic apoptotic pathway
N01048  Mutation-inactivated PINK1 to intrinsic apoptotic pathway
N01049  Mutation-inactivated PRKN to intrinsic apoptotic pathway
N01050  Mutation-inactivated PINK1 to intrinsic apoptotic pathway
N01135  Mutation-caused aberrant SOD1 to intrinsic apoptotic pathway
N01199  Scrapie conformation PrPSc to mGluR5-Ca2+ -apoptotic pathway
N01200  Scrapie conformation PrPSc to transport of calcium
Drug target
Rimiducid: D11195
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04370 VEGF signaling pathway
    842 (CASP9)
   04151 PI3K-Akt signaling pathway
    842 (CASP9)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    842 (CASP9)
   04215 Apoptosis - multiple species
    842 (CASP9)
   04115 p53 signaling pathway
    842 (CASP9)
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    842 (CASP9)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    842 (CASP9)
  09162 Cancer: specific types
   05210 Colorectal cancer
    842 (CASP9)
   05212 Pancreatic cancer
    842 (CASP9)
   05215 Prostate cancer
    842 (CASP9)
   05213 Endometrial cancer
    842 (CASP9)
   05222 Small cell lung cancer
    842 (CASP9)
   05223 Non-small cell lung cancer
    842 (CASP9)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    842 (CASP9)
   05161 Hepatitis B
    842 (CASP9)
   05160 Hepatitis C
    842 (CASP9)
   05164 Influenza A
    842 (CASP9)
   05162 Measles
    842 (CASP9)
   05168 Herpes simplex virus 1 infection
    842 (CASP9)
   05163 Human cytomegalovirus infection
    842 (CASP9)
   05167 Kaposi sarcoma-associated herpesvirus infection
    842 (CASP9)
   05169 Epstein-Barr virus infection
    842 (CASP9)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    842 (CASP9)
   05134 Legionellosis
    842 (CASP9)
   05152 Tuberculosis
    842 (CASP9)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    842 (CASP9)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    842 (CASP9)
   05012 Parkinson disease
    842 (CASP9)
   05014 Amyotrophic lateral sclerosis
    842 (CASP9)
   05016 Huntington disease
    842 (CASP9)
   05020 Prion disease
    842 (CASP9)
   05022 Pathways of neurodegeneration - multiple diseases
    842 (CASP9)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    842 (CASP9)
   05416 Viral myocarditis
    842 (CASP9)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    842 (CASP9)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    842 (CASP9)
   01002 Peptidases and inhibitors [BR:hsa01002]
    842 (CASP9)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.62  caspase-9
     842 (CASP9)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     842 (CASP9)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C14: caspase family
   842 (CASP9)
SSDB
Motif
Pfam: Peptidase_C14 CARD CARD_2 AsiA
Other DBs
NCBI-GeneID: 842
NCBI-ProteinID: NP_001220
OMIM: 602234
HGNC: 1511
Ensembl: ENSG00000132906
UniProt: P55211
Structure
LinkDB
Position
1:complement(15491401..15524912)
AA seq 416 aa
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR
TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ
ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS
TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
NT seq 1251 nt   +upstreamnt  +downstreamnt
atggacgaagcggatcggcggctcctgcggcggtgccggctgcggctggtggaagagctg
caggtggaccagctctgggacgccctgctgagccgcgagctgttcaggccccatatgatc
gaggacatccagcgggcaggctctggatctcggcgggatcaggccaggcagctgatcata
gatctggagactcgagggagtcaggctcttcctttgttcatctcctgcttagaggacaca
ggccaggacatgctggcttcgtttctgcgaactaacaggcaagcagcaaagttgtcgaag
ccaaccctagaaaaccttaccccagtggtgctcagaccagagattcgcaaaccagaggtt
ctcagaccggaaacacccagaccagtggacattggttctggaggatttggtgatgtcggt
gctcttgagagtttgaggggaaatgcagatttggcttacatcctgagcatggagccctgt
ggccactgcctcattatcaacaatgtgaacttctgccgtgagtccgggctccgcacccgc
actggctccaacatcgactgtgagaagttgcggcgtcgcttctcctcgctgcatttcatg
gtggaggtgaagggcgacctgactgccaagaaaatggtgctggctttgctggagctggcg
cagcaggaccacggtgctctggactgctgcgtggtggtcattctctctcacggctgtcag
gccagccacctgcagttcccaggggctgtctacggcacagatggatgccctgtgtcggtc
gagaagattgtgaacatcttcaatgggaccagctgccccagcctgggagggaagcccaag
ctctttttcatccaggcctgtggtggggagcagaaagaccatgggtttgaggtggcctcc
acttcccctgaagacgagtcccctggcagtaaccccgagccagatgccaccccgttccag
gaaggtttgaggaccttcgaccagctggacgccatatctagtttgcccacacccagtgac
atctttgtgtcctactctactttcccaggttttgtttcctggagggaccccaagagtggc
tcctggtacgttgagaccctggacgacatctttgagcagtgggctcactctgaagacctg
cagtccctcctgcttagggtcgctaatgctgtttcggtgaaagggatttataaacagatg
cctggttgctttaatttcctccggaaaaaacttttctttaaaacatcataa

DBGET integrated database retrieval system