| Entry |
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| Name |
Mutation-inactivated PRKN to intrinsic apoptotic pathway
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| Definition |
PRKN* // BAX -> CYCS == APAF1 -> CASP9 -> CASP3 |
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| Expanded |
5071v1 // 581 -> 54205 == 317 -> 842 -> 836 |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
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| Gene |
| 5071 | PRKN; parkin RBR E3 ubiquitin protein ligase |
| 581 | BAX; BCL2 associated X, apoptosis regulator |
| 54205 | CYCS; cytochrome c, somatic |
| 317 | APAF1; apoptotic peptidase activating factor 1 |
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| Variant |
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| Reference |
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| Authors |
Charan RA, Johnson BN, Zaganelli S, Nardozzi JD, LaVoie MJ |
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| Title |
Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin. |
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| Journal |
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| Reference |
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| Authors |
Franco-Iborra S, Vila M, Perier C |
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| Title |
The Parkinson Disease Mitochondrial Hypothesis: Where Are We at? |
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| Journal |
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| Reference |
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| Authors |
Bose A, Beal MF |
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| Title |
Mitochondrial dysfunction in Parkinson's disease. |
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| Journal |
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| Reference |
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| Authors |
Bernardini JP, Brouwer JM, Tan IK, Sandow JJ, Huang S, Stafford CA, Bankovacki A, Riffkin CD, Wardak AZ, Czabotar PE, Lazarou M, Dewson G |
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| Title |
Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy. |
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| Journal |
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| LinkDB |
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