| Entry |
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| Name |
LPA-GNA12/13-RhoA signaling pathway
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| Definition |
LPA -> LPAR -> GNA12/13 -> (ARHGEF12,ARHGEF1,ARHGEF11) -> RHOA -> ROCK1/2 |
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| Expanded |
C00681 -> (1902,9170,23566,2846,57121) -> (2768,10672) -> (23365,9138,9826) -> 387 -> (6093,9475) |
|---|
| Class |
nt06180 Pathogenic Escherichia coli
|
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| Type |
Reference
|
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| Pathway |
| hsa04810 | Regulation of actin cytoskeleton |
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| Gene |
| 1902 | LPAR1; lysophosphatidic acid receptor 1 |
| 9170 | LPAR2; lysophosphatidic acid receptor 2 |
| 23566 | LPAR3; lysophosphatidic acid receptor 3 |
| 2846 | LPAR4; lysophosphatidic acid receptor 4 |
| 57121 | LPAR5; lysophosphatidic acid receptor 5 |
| 2768 | GNA12; G protein subunit alpha 12 |
| 10672 | GNA13; G protein subunit alpha 13 |
| 23365 | ARHGEF12; Rho guanine nucleotide exchange factor 12 |
| 9138 | ARHGEF1; Rho guanine nucleotide exchange factor 1 |
| 9826 | ARHGEF11; Rho guanine nucleotide exchange factor 11 |
| 387 | RHOA; ras homolog family member A |
| 6093 | ROCK1; Rho associated coiled-coil containing protein kinase 1 |
| 9475 | ROCK2; Rho associated coiled-coil containing protein kinase 2 |
|
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| Metabolite |
| C00681 | 1-Acyl-sn-glycerol 3-phosphate |
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| Reference |
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| Authors |
Kozasa T, Hajicek N, Chow CR, Suzuki N |
|---|
| Title |
Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13. |
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| Journal |
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| Reference |
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| Authors |
O'Connor K, Chen M |
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| Title |
Dynamic functions of RhoA in tumor cell migration and invasion. |
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| Journal |
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| Reference |
|
|---|
| Authors |
Riaz A, Huang Y, Johansson S |
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| Title |
G-Protein-Coupled Lysophosphatidic Acid Receptors and Their Regulation of AKT Signaling. |
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| Journal |
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| LinkDB |
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