KEGG   NETWORK: N01130
Entry
N01130                      Network                                
Name
Salmonella SopB to RhoA signaling pathway
Definition
SopB -> RHOA -> ROCK2 -> MLC
  Expanded
K13085 -> 387 -> 9475 -> (103910,10398,10627,29895,4633,4636,58498,93408)
Class
nt06135 Cytoskeletal regulation (viruses and bacteria)
Type
Pathogen
Pathway
hsa05132  Salmonella infection
Disease
H00113  Salmonellosis
Gene
387  RHOA; ras homolog family member A
9475  ROCK2; Rho associated coiled-coil containing protein kinase 2
103910  MYL12B; myosin light chain 12B
10398  MYL9; myosin light chain 9
10627  MYL12A; myosin light chain 12A
29895  MYLPF; myosin light chain, phosphorylatable, fast skeletal muscle
4633  MYL2; myosin light chain 2
4636  MYL5; myosin light chain 5
58498  MYL7; myosin light chain 7
93408  MYL10; myosin light chain 10
Perturbant
K13085 (SopB)  ipgD; phosphatidylinositol-4,5-bisphosphate 4-phosphatase
Reference
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
  Authors
Truong D, Brabant D, Bashkurov M, Wan LC, Braun V, Heo WD, Meyer T, Pelletier L, Copeland J, Brumell JH
  Title
Formin-mediated actin polymerization promotes Salmonella invasion.
  Journal
Cell Microbiol 15:2051-63 (2013)
DOI:10.1111/cmi.12173
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