KEGG   NETWORK: N01292
Entry
N01292                      Network                                

Name
Escherichia EspG to RAB1 signaling pathway
Definition
(EspG,EspG2) -| RAB1
  Expanded
(K12785,K12809) -| (5861,81876)
Class
nt06125 Membrane trafficking (bacteria)
Type
Pathogen
Pathway
hsa05130  Pathogenic Escherichia coli infection
Disease
H00277  Enterohemorrhagic Escherichia coli (EHEC) infection
H00278  Enteropathogenic Escherichia coli (EPEC) infection
Gene
5861  RAB1A; RAB1A, member RAS oncogene family
81876  RAB1B; RAB1B, member RAS oncogene family
Perturbant
K12785 (EspG)  espG; LEE-encoded effector EspG
K12809 (EspG2)  espG2; T3SS secreted effector EspG-like protein
Reference
  Authors
Dong N, Zhu Y, Lu Q, Hu L, Zheng Y, Shao F
  Title
Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses.
  Journal
Cell 150:1029-41 (2012)
DOI:10.1016/j.cell.2012.06.050
Reference
  Authors
Reddick LE, Alto NM
  Title
Bacteria fighting back: how pathogens target and subvert the host innate immune system.
  Journal
Mol Cell 54:321-8 (2014)
DOI:10.1016/j.molcel.2014.03.010
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