KEGG   NETWORK: N01302
Entry
N01302                      Network                                

Name
Early endosomal fusion
Definition
(RABGEF1+RABEP1) -> RAB5 -> (PIK3C3+PIK3R4) -> PI3P -> EEA1
  Expanded
(27342+9135) -> (5868,5869,5878) -> (5289+30849) -> C04549 -> 8411
Class
nt06125 Membrane trafficking (bacteria)
Type
Reference
Pathway
hsa04145  Phagosome
Gene
27342  RABGEF1; RAB guanine nucleotide exchange factor 1
9135  RABEP1; rabaptin, RAB GTPase binding effector protein 1
5868  RAB5A; RAB5A, member RAS oncogene family
5869  RAB5B; RAB5B, member RAS oncogene family
5878  RAB5C; RAB5C, member RAS oncogene family
5289  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3
30849  PIK3R4; phosphoinositide-3-kinase regulatory subunit 4
8411  EEA1; early endosome antigen 1
Metabolite
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Woodman PG
  Title
Biogenesis of the sorting endosome: the role of Rab5.
  Journal
Traffic 1:695-701 (2000)
DOI:10.1034/j.1600-0854.2000.010902.x
Reference
  Authors
Grosshans BL, Ortiz D, Novick P
  Title
Rabs and their effectors: achieving specificity in membrane traffic.
  Journal
Proc Natl Acad Sci U S A 103:11821-7 (2006)
DOI:10.1073/pnas.0601617103
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