Homo sapiens (human): 5289
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Entry
5289 CDS
T01001
Symbol
PIK3C3, VPS34, hVps34
Name
(RefSeq) phosphatidylinositol 3-kinase catalytic subunit type 3
KO
K00914
phosphatidylinositol 3-kinase [EC:
2.7.1.137
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00562
Inositol phosphate metabolism
hsa01100
Metabolic pathways
hsa04070
Phosphatidylinositol signaling system
hsa04136
Autophagy - other
hsa04140
Autophagy - animal
hsa04145
Phagosome
hsa04371
Apelin signaling pathway
hsa05010
Alzheimer disease
hsa05014
Amyotrophic lateral sclerosis
hsa05016
Huntington disease
hsa05017
Spinocerebellar ataxia
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05131
Shigellosis
hsa05132
Salmonella infection
hsa05152
Tuberculosis
hsa05167
Kaposi sarcoma-associated herpesvirus infection
Network
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06181
Salmonella
nt06461
Huntington disease
nt06462
Spinocerebellar ataxia
nt06466
Pathways of neurodegeneration
nt06532
Autophagy
Element
N00155
Autophagy-vesicle nucleation/elongation/maturation, mTORC1-PI3KC3-C1
N00177
KSHV vBCL2 to autophagy-vesicle nucleation
N00962
Mutation-inactivated ATXN3 to autophagy-vesicle nucleation
N00993
Mutation-caused aberrant Htt to autophagy-vesicle nucleation
N01302
Early endosomal fusion
N01303
Salmonella SopB to Early endosomal fusion
N01715
Autophagy-vesicle nucleation/elongation/maturation, PI3P synthesis by PI3KC3-C1
N01718
Autophagy-vesicle nucleation/elongation/maturation, PACER-RUBCN-PI3KC3-C2
N01719
Autophagy-vesicle nucleation/elongation/maturation, E3 ubiquitin-ligase Malin
Drug target
Fimepinostat:
D11319
Safingol:
D05784
Safingol hydrochloride:
D05785
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
5289 (PIK3C3)
09130 Environmental Information Processing
09132 Signal transduction
04371 Apelin signaling pathway
5289 (PIK3C3)
04070 Phosphatidylinositol signaling system
5289 (PIK3C3)
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagosome
5289 (PIK3C3)
04140 Autophagy - animal
5289 (PIK3C3)
04136 Autophagy - other
5289 (PIK3C3)
09160 Human Diseases
09172 Infectious disease: viral
05167 Kaposi sarcoma-associated herpesvirus infection
5289 (PIK3C3)
09171 Infectious disease: bacterial
05132 Salmonella infection
5289 (PIK3C3)
05131 Shigellosis
5289 (PIK3C3)
05152 Tuberculosis
5289 (PIK3C3)
09164 Neurodegenerative disease
05010 Alzheimer disease
5289 (PIK3C3)
05014 Amyotrophic lateral sclerosis
5289 (PIK3C3)
05016 Huntington disease
5289 (PIK3C3)
05017 Spinocerebellar ataxia
5289 (PIK3C3)
05022 Pathways of neurodegeneration - multiple diseases
5289 (PIK3C3)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
5289 (PIK3C3)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.1 Phosphotransferases with an alcohol group as acceptor
2.7.1.137 phosphatidylinositol 3-kinase
5289 (PIK3C3)
Membrane trafficking [BR:
hsa04131
]
Endocytosis
Macropinocytosis
Kinases
5289 (PIK3C3)
Rab GTPases and associated proteins
Rab associated proteins
5289 (PIK3C3)
Endosome - Lysosome transport
5289 (PIK3C3)
Autophagy
Autophagosome formation proteins
PI3K complex
5289 (PIK3C3)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PI3_PI4_kinase
PI3Ka
PI3K_C2
HEAT_2
Motif
Other DBs
NCBI-GeneID:
5289
NCBI-ProteinID:
NP_002638
OMIM:
602609
HGNC:
8974
Ensembl:
ENSG00000078142
UniProt:
Q8NEB9
Structure
PDB
LinkDB
All DBs
Position
18:41955234..42087830
Genome browser
AA seq
887 aa
AA seq
DB search
MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVT
CQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAV
PVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTK
AHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDG
DESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIV
SYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDV
EDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKK
DSQSSVSENVSNSGINSAEIDSSQIITSPLPSVSSPPPASKTKEVPDGENLEQDLCTFLI
SRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRS
LLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVK
IRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRK
ENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAE
VMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLN
KEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVK
KVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK
NT seq
2664 nt
NT seq
+upstream
nt +downstream
nt
atgggggaagcagagaagtttcactacatctatagttgtgacctggatatcaacgtccag
cttaagataggaagcttggaagggaagagagaacaaaagagttataaagctgtcctggaa
gacccaatgttgaagttctcaggactatatcaagagacatgctctgatctttatgttact
tgtcaagtttttgcagaagggaagcctttggccttgccagtgagaacatcctacaaagca
tttagtacaagatggaactggaatgaatggctgaaactaccagtaaaataccctgacctg
cccaggaatgcccaagtggccctcaccatatgggatgtgtatggtcccggaaaagcagtg
cctgtaggaggaacaacggtttcgctctttggaaaatacggcatgtttcgccaagggatg
catgacttgaaagtctggcctaatgtagaagcagatggatcagaacccacaaaaactcct
ggcagaacaagtagcactctctcagaagatcagatgagccgtcttgccaagctcaccaaa
gctcatcgacaaggacacatggtgaaagtagattggctggatagattgacatttagagaa
atagaaatgataaatgagagtgaaaaacgaagttctaatttcatgtacctgatggttgaa
tttcgatgtgtcaagtgtgatgataaggaatatggtattgtttattatgaaaaggacggt
gatgaatcatctccaattttaacaagttttgaattagtgaaagttcctgacccccagatg
tctatggagaatttagttgagagcaaacaccacaagcttgcccggagtttaagaagtgga
ccttctgaccacgatctgaaacccaatgctgccacgagagatcagttaaatattattgtg
agttatccaccaaccaagcaacttacatatgaagaacaagatcttgtttggaagtttaga
tattatcttacgaatcaagaaaaagccttgacaaaattcttgaaatgtgttaattgggat
ctacctcaagaggccaaacaggccttggaacttctgggaaaatggaagccgatggatgta
gaggactccttggagctgttatcctctcattacaccaacccaactgtgaggcgttatgct
gttgcccggttgcgacaggccgatgatgaggatttgttgatgtacctattacaattggtc
caggctctcaaatatgaaaattttgatgatataaagaatggattggaacctaccaagaag
gatagtcagagttcagtgtcagaaaatgtgtcaaattctggaataaattctgcagaaata
gatagctcccaaattataaccagcccccttccttcagtctcttcacctcctcctgcatca
aaaacaaaagaagttccagatggcgaaaatctggaacaagatctctgtaccttcttgata
tcgagagcctgcaaaaactcaacactggctaattatttatactggtatgtgatagtggaa
tgtgaagatcaagatactcagcagagagatccaaagacccatgagatgtacttgaacgta
atgagaagattcagccaagcattgttgaagggtgataagtctgtcagagttatgcgttct
ttgctggctgcacaacagacatttgtagatcggttggtgcatctaatgaaggcagtacaa
cgcgaaagtggaaatcgtaagaaaaagaatgagagactacaggcattgcttggagataat
gaaaagatgaatttgtcagatgtggaacttatcccgttgcctttagaaccccaagtgaaa
attagaggaataattccggaaacagctacactgtttaaaagtgcccttatgcctgcacag
ttgttttttaagacggaagatggaggcaaatatccagttatatttaagcatggagatgat
ttacgtcaagatcaacttattcttcaaatcatttcactcatggacaagctgttacggaaa
gaaaatctggacttgaaattgacaccttataaggtgttagccaccagtacaaaacatggc
ttcatgcagtttatccagtcagttcctgtggctgaagttcttgatacagagggaagcatt
cagaacttttttagaaaatatgcaccaagtgagaatgggccaaatgggattagtgctgag
gtcatggacacttacgttaaaagctgtgctggatattgcgtgatcacctatatacttgga
gttggagacaggcacctggataaccttttgctaacaaaaacaggcaaactcttccacata
gactttggatatattttgggtcgggatccaaagcctcttcctccaccaatgaagctgaat
aaagaaatggtagaaggaatggggggcacacagagtgagcagtaccaagagttccgtaaa
cagtgttacacggctttcctccacctgcgaaggtattctaatctgattttgaacttgttt
tccttgatggttgatgcaaacattccagatattgcacttgaaccagataaaactgtgaaa
aaggttcaggataaattccgcttagacctgtcggatgaagaggctgtgcattacatgcag
agtctgattgatgagagtgtccatgctctttttgctgcagtggtggaacagattcacaag
tttgcccagtactggagaaaatga
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integrated database retrieval system
