KEGG   NETWORK: N01312
Entry
N01312                      Network                                

Name
SARS-CoV-2 S to lectin pathway of complement activation
Definition
S -> (MBL2+MASP1/2) -> (C2+C4) -> C3 -> (C5+C6+C7+C8+C9))
  Expanded
K24152 -> (4153+(5648,10747)) -> (717+(720,721)) -> 718 -> (727+729+730+(731,732,733)+735)
Class
nt06136 Complement activation (viruses)
nt06171 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Type
Pathogen
Pathway
hsa05171  Coronavirus disease - COVID-19
Disease
H02398  COVID-19
Gene
4153  MBL2; mannose binding lectin 2
5648  MASP1; mannan binding lectin serine peptidase 1
10747  MASP2; mannan binding lectin serine peptidase 2
717  C2; complement C2
720  C4A; complement C4A (Rodgers blood group)
721  C4B; complement C4B (Chido blood group)
718  C3; complement C3
727  C5; complement C5
729  C6; complement C6
730  C7; complement C7
731  C8A; complement C8 alpha chain
732  C8B; complement C8 beta chain
733  C8G; complement C8 gamma chain
735  C9; complement C9
Perturbant
K24152 (S)  S; SARS coronavirus spike glycoprotein
Reference
  Authors
Noris M, Benigni A, Remuzzi G
  Title
The case of complement activation in COVID-19 multiorgan impact.
  Journal
Kidney Int 98:314-322 (2020)
DOI:10.1016/j.kint.2020.05.013
Reference
  Authors
Jodele S, Kohl J
  Title
Tackling COVID-19 infection through complement-targeted immunotherapy.
  Journal
Br J Pharmacol (2020)
DOI:10.1111/bph.15187
Reference
  Authors
Chauhan AJ, Wiffen LJ, Brown TP
  Title
COVID-19: A collision of complement, coagulation and inflammatory pathways.
  Journal
J Thromb Haemost (2020)
DOI:10.1111/jth.14981
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