KEGG   NETWORK: N01312
Entry
N01312                      Network                                
Name
SARS-CoV-2 S to lectin pathway of complement cascade
Definition
S -> (MBL2+MASP1/2)
  Expanded
K24152 -> (4153+(5648,10747))
Class
nt06513 Complement cascade
nt06171 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Type
Pathogen
Pathway
hsa05171  Coronavirus disease - COVID-19
Disease
H02398  COVID-19
Gene
4153  MBL2; mannose binding lectin 2
5648  MASP1; mannan binding lectin serine peptidase 1
10747  MASP2; mannan binding lectin serine peptidase 2
Perturbant
K24152 (S)  S; SARS coronavirus spike glycoprotein
Reference
  Authors
Noris M, Benigni A, Remuzzi G
  Title
The case of complement activation in COVID-19 multiorgan impact.
  Journal
Kidney Int 98:314-322 (2020)
DOI:10.1016/j.kint.2020.05.013
Reference
  Authors
Jodele S, Kohl J
  Title
Tackling COVID-19 infection through complement-targeted immunotherapy.
  Journal
Br J Pharmacol (2020)
DOI:10.1111/bph.15187
Reference
  Authors
Chauhan AJ, Wiffen LJ, Brown TP
  Title
COVID-19: A collision of complement, coagulation and inflammatory pathways.
  Journal
J Thromb Haemost (2020)
DOI:10.1111/jth.14981
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