KEGG   NETWORK: N01321
Entry
N01321                      Network                                

Name
SARS-CoV-2 nsp1/6/13, ORF3a/6/7b and M to IFN signaling pathway
Definition
(nsp1,nsp6,nsp13,ORF3a,ORF6,ORF7b,M) -| STAT1
  Expanded
(K25011,K25016,K25022,K24579,K24580,K24582,K24150) -| 6772
Class
nt06122 IFN signaling (viruses)
nt06171 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Type
Variant
Pathway
hsa05171  Coronavirus disease - COVID-19
Disease
H02398  COVID-19
Gene
6772  STAT1; signal transducer and activator of transcription 1
Perturbant
K25011 (nsp1)  nsp1; SARS coronavirus host translation inhibitor nsp1
K25016 (nsp6)  nsp6; SARS coronavirus non-structural protein 6
K25022 (nsp13)  nsp13; SARS coronavirus helicase
K24579 (ORF3a)  3a; SARS coronavirus accessory protein 3a
K24580 (ORF6)  6; SARS coronavirus accessory protein 6
K24582 (ORF7b)  7b; SARS coronavirus accessory protein 7b
K24150 (M)  M; SARS coronavirus membrane protein
Reference
  Authors
Xia H, Cao Z, Xie X, Zhang X, Chen JY, Wang H, Menachery VD, Rajsbaum R, Shi PY
  Title
Evasion of Type I Interferon by SARS-CoV-2.
  Journal
Cell Rep 33:108234 (2020)
DOI:10.1016/j.celrep.2020.108234
Reference
  Authors
Harrison AG, Lin T, Wang P
  Title
Mechanisms of SARS-CoV-2 Transmission and Pathogenesis.
  Journal
Trends Immunol S1471-4906(20)30233-7 (2020)
DOI:10.1016/j.it.2020.10.004
Reference
  Authors
Yuen CK, Lam JY, Wong WM, Mak LF, Wang X, Chu H, Cai JP, Jin DY, To KK, Chan JF, Yuen KY, Kok KH
  Title
SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists.
  Journal
Emerg Microbes Infect 9:1418-1428 (2020)
DOI:10.1080/22221751.2020.1780953
Reference
  Authors
Lei X, Dong X, Ma R, Wang W, Xiao X, Tian Z, Wang C, Wang Y, Li L, Ren L, Guo F, Zhao Z, Zhou Z, Xiang Z, Wang J
  Title
Activation and evasion of type I interferon responses by SARS-CoV-2.
  Journal
Nat Commun 11:3810 (2020)
DOI:10.1038/s41467-020-17665-9
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