KEGG   NETWORK: N01337
Entry
N01337                      Network                                
Name
NNK/NNN to CHRNA7-E2F signaling pathway
Definition
(NNK,NNN) -> CHRNA7 -> ARRB1 -> SRC -> RAF1 -> RB1 // E2F1 => (BIRC5,XIAP,CDC6,CDC25A)
  Expanded
(C16453,C16452) -> 1139 -> 408 -> 6714 -> 5894 -> 5925 // 1869 => (332,331,990,993)
Class
nt06230 Cell cycle
Type
Env factor
Pathway
hsa05207  Chemical carcinogenesis - receptor activation
Disease
H00014  Non-small cell lung cancer
Gene
1139  CHRNA7; cholinergic receptor nicotinic alpha 7 subunit
408  ARRB1; arrestin beta 1
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
332  BIRC5; baculoviral IAP repeat containing 5
331  XIAP; X-linked inhibitor of apoptosis
990  CDC6; cell division cycle 6
993  CDC25A; cell division cycle 25A
Perturbant
C16453 (NNK)  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16452 (NNN)  N'-Nitrosonornicotine
Reference
  Authors
Dasgupta P, Rastogi S, Pillai S, Ordonez-Ercan D, Morris M, Haura E, Chellappan S
  Title
Nicotine induces cell proliferation by beta-arrestin-mediated activation of Src and Rb-Raf-1 pathways.
  Journal
J Clin Invest 116:2208-2217 (2006)
DOI:10.1172/JCI28164
Reference
  Authors
Wen J, Fu JH, Zhang W, Guo M
  Title
Lung carcinoma signaling pathways activated by smoking.
  Journal
Chin J Cancer 30:551-8 (2011)
DOI:10.5732/cjc.011.10059
Reference
  Authors
Singh S, Pillai S, Chellappan S
  Title
Nicotinic acetylcholine receptor signaling in tumor growth and metastasis.
  Journal
J Oncol 2011:456743 (2011)
DOI:10.1155/2011/456743
Reference
  Authors
Schaal C, Chellappan SP
  Title
Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers.
  Journal
Mol Cancer Res 12:14-23 (2014)
DOI:10.1158/1541-7786.MCR-13-0541
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