| Entry |
|
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| Name |
NNK/NNN to CHRNA7-E2F signaling pathway
|
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| Definition |
(NNK,NNN) -> CHRNA7 -> ARRB1 -> SRC -> RAF1 -> RB1 // E2F1 => (BIRC5,XIAP,CDC6,CDC25A) |
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| Expanded |
(C16453,C16452) -> 1139 -> 408 -> 6714 -> 5894 -> 5925 // 1869 => (332,331,990,993) |
|---|
| Class |
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| Type |
Env factor
|
|---|
| Pathway |
| hsa05207 | Chemical carcinogenesis - receptor activation |
|
|---|
| Disease |
| H00014 | Non-small cell lung cancer |
|
|---|
| Gene |
| 1139 | CHRNA7; cholinergic receptor nicotinic alpha 7 subunit |
| 408 | ARRB1; arrestin beta 1 |
| 6714 | SRC; SRC proto-oncogene, non-receptor tyrosine kinase |
| 5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
| 5925 | RB1; RB transcriptional corepressor 1 |
| 1869 | E2F1; E2F transcription factor 1 |
| 332 | BIRC5; baculoviral IAP repeat containing 5 |
| 331 | XIAP; X-linked inhibitor of apoptosis |
| 990 | CDC6; cell division cycle 6 |
| 993 | CDC25A; cell division cycle 25A |
|
|---|
| Perturbant |
| C16453 (NNK) | 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone |
| C16452 (NNN) | N'-Nitrosonornicotine |
|
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| Reference |
|
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| Authors |
Dasgupta P, Rastogi S, Pillai S, Ordonez-Ercan D, Morris M, Haura E, Chellappan S |
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| Title |
Nicotine induces cell proliferation by beta-arrestin-mediated activation of Src and Rb-Raf-1 pathways. |
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| Journal |
|
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| Reference |
|
|---|
| Authors |
Wen J, Fu JH, Zhang W, Guo M |
|---|
| Title |
Lung carcinoma signaling pathways activated by smoking. |
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| Journal |
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| Reference |
|
|---|
| Authors |
Singh S, Pillai S, Chellappan S |
|---|
| Title |
Nicotinic acetylcholine receptor signaling in tumor growth and metastasis. |
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| Journal |
|
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| Reference |
|
|---|
| Authors |
Schaal C, Chellappan SP |
|---|
| Title |
Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers. |
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| Journal |
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| LinkDB |
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