| Entry |
|
|---|
| Name |
NNK/NNN to PI3K signaling pathway
|
|---|
| Definition |
(NNK,NNN) -> CHRNA7 -> Ca2+ -> PI3K -> PIP3 -> AKT -> (MTOR,NFKB,BIRC5) |
|---|
| Expanded |
(C16453,C16452) -> 1139 -> C00076 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> (2475,(4790+5970),332) |
|---|
| Class |
|
|---|
| Type |
Env factor
|
|---|
| Pathway |
| hsa05207 | Chemical carcinogenesis - receptor activation |
|
|---|
| Disease |
| H00014 | Non-small cell lung cancer |
|
|---|
| Gene |
| 1139 | CHRNA7; cholinergic receptor nicotinic alpha 7 subunit |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
| 2475 | MTOR; mechanistic target of rapamycin kinase |
| 4790 | NFKB1; nuclear factor kappa B subunit 1 |
| 5970 | RELA; RELA proto-oncogene, NF-kB subunit |
| 332 | BIRC5; baculoviral IAP repeat containing 5 |
|
|---|
| Perturbant |
| C16453 (NNK) | 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone |
| C16452 (NNN) | N'-Nitrosonornicotine |
|
|---|
| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
|---|
| Reference |
|
|---|
| Authors |
Wen J, Fu JH, Zhang W, Guo M |
|---|
| Title |
Lung carcinoma signaling pathways activated by smoking. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Improgo MR, Tapper AR, Gardner PD |
|---|
| Title |
Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Wu CH, Lee CH, Ho YS |
|---|
| Title |
Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy. |
|---|
| Journal |
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| LinkDB |
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