KEGG   NETWORK: N01339
Entry
N01339                      Network                                

Name
NNK/NNN to PI3K signaling pathway
Definition
(NNK,NNN) -> CHRNA7 -> Ca2+ -> PI3K -> PIP3 -> AKT -> (MTOR,NFKB,BIRC5)
  Expanded
(C16453,C16452) -> 1139 -> C00076 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> (2475,(4790+5970),332)
Class
nt06214 PI3K signaling
Type
Env factor
Pathway
hsa05207  Chemical carcinogenesis - receptor activation
Disease
H00014  Non-small cell lung cancer
Gene
1139  CHRNA7; cholinergic receptor nicotinic alpha 7 subunit
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2475  MTOR; mechanistic target of rapamycin kinase
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
332  BIRC5; baculoviral IAP repeat containing 5
Perturbant
C16453 (NNK)  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16452 (NNN)  N'-Nitrosonornicotine
Metabolite
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Wen J, Fu JH, Zhang W, Guo M
  Title
Lung carcinoma signaling pathways activated by smoking.
  Journal
Chin J Cancer 30:551-8 (2011)
DOI:10.5732/cjc.011.10059
Reference
  Authors
Improgo MR, Tapper AR, Gardner PD
  Title
Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer.
  Journal
Biochem Pharmacol 82:1015-21 (2011)
DOI:10.1016/j.bcp.2011.05.020
Reference
  Authors
Wu CH, Lee CH, Ho YS
  Title
Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.
  Journal
Clin Cancer Res 17:3533-41 (2011)
DOI:10.1158/1078-0432.CCR-10-2434
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