KEGG   NETWORK: N01349
Entry
N01349                      Network                                

Name
ACH-CHRN-PI3K signaling pathway
Definition
ACh -> CHRNA7 -> PI3K -> PIP3 -> AKT
  Expanded
C01996 -> 1139 -> (5290,5291,5293) -> C05981 -> (207,208,10000)
Class
nt06214 PI3K signaling
Type
Reference
Gene
1139  CHRNA7; cholinergic receptor nicotinic alpha 7 subunit
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
Metabolite
C01996  Acetylcholine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Wu CH, Lee CH, Ho YS
  Title
Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.
  Journal
Clin Cancer Res 17:3533-41 (2011)
DOI:10.1158/1078-0432.CCR-10-2434
Reference
  Authors
Gankhuyag N, Lee KH, Cho JY
  Title
The Role of Nitrosamine (NNK) in Breast Cancer Carcinogenesis.
  Journal
J Mammary Gland Biol Neoplasia 22:159-170 (2017)
DOI:10.1007/s10911-017-9381-z
Reference
  Authors
Akaike A, Izumi Y
  Title
Overview
  Journal
Nicotinic Acetylcholine Receptor Signaling in Neuroprotection(2018)
DOI:10.1007/978-981-10-8488-1
Reference
  Authors
Dajas-Bailador F, Wonnacott S
  Title
Nicotinic acetylcholine receptors and the regulation of neuronal signalling.
  Journal
Trends Pharmacol Sci 25:317-24 (2004)
DOI:10.1016/j.tips.2004.04.006
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