| Entry |
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| Name |
E2 to nuclear-initiated estrogen signaling pathway
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| Definition |
E2 -> ESR1/2 => (EGF,FGF9,DLL) |
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| Expanded |
C00951 -> (2099,2100) => (1950,2254,28514,10683,54567) |
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| Class |
nt06227 Nuclear receptor signaling (cancer)
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| Type |
Env factor
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| Pathway |
| hsa05207 | Chemical carcinogenesis - receptor activation |
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| Disease |
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| Gene |
| 2099 | ESR1; estrogen receptor 1 |
| 2100 | ESR2; estrogen receptor 2 |
| 1950 | EGF; epidermal growth factor |
| 2254 | FGF9; fibroblast growth factor 9 |
| 28514 | DLL1; delta like canonical Notch ligand 1 |
| 10683 | DLL3; delta like canonical Notch ligand 3 |
| 54567 | DLL4; delta like canonical Notch ligand 4 |
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| Perturbant |
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| Reference |
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| Authors |
Finlay-Schultz J, Sartorius CA |
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| Title |
Steroid hormones, steroid receptors, and breast cancer stem cells. |
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| Journal |
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| Reference |
|
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| Authors |
Chen B, Ye P, Chen Y, Liu T, Cha JH, Yan X, Yang WH |
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| Title |
Involvement of the Estrogen and Progesterone Axis in Cancer Stemness: Elucidating Molecular Mechanisms and Clinical Significance. |
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| Journal |
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| Reference |
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|---|
| Authors |
Harrison H, Simoes BM, Rogerson L, Howell SJ, Landberg G, Clarke RB |
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| Title |
Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signalling. |
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| Journal |
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| Reference |
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| Authors |
Mallepell S, Krust A, Chambon P, Brisken C |
|---|
| Title |
Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland. |
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| Journal |
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| LinkDB |
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