KEGG   NETWORK: N01365
Entry
N01365                      Network                                

Name
TCDD to Ahr signaling pathway
Definition
TCDD -> (AHR+ARNT) => (CYP1A1,CYP1B1,GST)
  Expanded
C07557 -> (196+405) => (1543,1545,(119391,221357,2938,2939,2940,2941,2944,2946,2947,2948,2949,2950,2952,2953,4257,4258,4259,653689,9446))
Class
nt06227 Nuclear receptor signaling
Type
Env factor
Pathway
hsa05207  Chemical carcinogenesis - receptor activation
Disease
H00048  Hepatocellular carcinoma
H00014  Non-small cell lung cancer
Gene
196  AHR; aryl hydrocarbon receptor
405  ARNT; aryl hydrocarbon receptor nuclear translocator
1543  CYP1A1; cytochrome P450 family 1 subfamily A member 1
1545  CYP1B1; cytochrome P450 family 1 subfamily B member 1
119391  GSTO2; glutathione S-transferase omega 2
221357  GSTA5; glutathione S-transferase alpha 5
2938  GSTA1; glutathione S-transferase alpha 1
2939  GSTA2; glutathione S-transferase alpha 2
2940  GSTA3; glutathione S-transferase alpha 3
2941  GSTA4; glutathione S-transferase alpha 4
2944  GSTM1; glutathione S-transferase mu 1
2946  GSTM2; glutathione S-transferase mu 2
2947  GSTM3; glutathione S-transferase mu 3
2948  GSTM4; glutathione S-transferase mu 4
2949  GSTM5; glutathione S-transferase mu 5
2950  GSTP1; glutathione S-transferase pi 1
2952  GSTT1; glutathione S-transferase theta 1
2953  GSTT2; glutathione S-transferase theta 2 (gene/pseudogene)
4257  MGST1; microsomal glutathione S-transferase 1
4258  MGST2; microsomal glutathione S-transferase 2
4259  MGST3; microsomal glutathione S-transferase 3
653689  GSTT2B; glutathione S-transferase theta 2B
9446  GSTO1; glutathione S-transferase omega 1
Perturbant
C07557 (TCDD)  2,3,7,8-Tetrachlorodibenzodioxin
Reference
  Authors
Mandal PK
  Title
Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology.
  Journal
J Comp Physiol B 175:221-30 (2005)
DOI:10.1007/s00360-005-0483-3
Reference
  Authors
Luch A.
  Title
Nature and nurture - lessons from chemical carcinogenesis.
  Journal
Nat Rev Cancer 5:113-25 (2005)
DOI:10.1038/nrc1546
Reference
  Authors
Hidaka T, Fujimura T, Aiba S
  Title
Aryl Hydrocarbon Receptor Modulates Carcinogenesis and Maintenance of Skin Cancers.
  Journal
Front Med (Lausanne) 6:194 (2019)
DOI:10.3389/fmed.2019.00194
Reference
  Authors
Mimura J, Fujii-Kuriyama Y
  Title
Functional role of AhR in the expression of toxic effects by TCDD.
  Journal
Biochim Biophys Acta 1619:263-8 (2003)
DOI:10.1016/s0304-4165(02)00485-3
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