| Entry |
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| Name |
BaP to Ahr signaling pathway
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| Definition |
BaP -> (AHR+ARNT) => (CYP1A1,CYP1B1) |
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| Expanded |
C07535 -> (196+405) => (1543,1545) |
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| Class |
nt06227 Nuclear receptor signaling (cancer)
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| Type |
Env factor
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| Pathway |
| hsa05207 | Chemical carcinogenesis - receptor activation |
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| Disease |
| H00048 | Hepatocellular carcinoma |
| H00014 | Non-small cell lung cancer |
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| Gene |
| 196 | AHR; aryl hydrocarbon receptor |
| 405 | ARNT; aryl hydrocarbon receptor nuclear translocator |
| 1543 | CYP1A1; cytochrome P450 family 1 subfamily A member 1 |
| 1545 | CYP1B1; cytochrome P450 family 1 subfamily B member 1 |
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| Perturbant |
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| Reference |
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| Authors |
Shimizu Y, Nakatsuru Y, Ichinose M, Takahashi Y, Kume H, Mimura J, Fujii-Kuriyama Y, Ishikawa T |
|---|
| Title |
Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor. |
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| Journal |
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| Reference |
|
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| Authors |
Luch A. |
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| Title |
Nature and nurture - lessons from chemical carcinogenesis. |
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| Journal |
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| Reference |
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| Authors |
Hidaka T, Fujimura T, Aiba S |
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| Title |
Aryl Hydrocarbon Receptor Modulates Carcinogenesis and Maintenance of Skin Cancers. |
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| Journal |
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| Reference |
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| Authors |
Shi S, Yoon DY, Hodge-Bell KC, Bebenek IG, Whitekus MJ, Zhang R, Cochran AJ, Huerta-Yepez S, Yim SH, Gonzalez FJ, Jaiswal AK, Hankinson O |
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| Title |
The aryl hydrocarbon receptor nuclear translocator (Arnt) is required for tumor initiation by benzo[a]pyrene. |
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| Journal |
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| LinkDB |
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