KEGG   NETWORK: N01366
Entry
N01366                      Network                                

Name
BaP to Ahr signaling pathway
Definition
BaP -> (AHR+ARNT) => (CYP1A1,CYP1B1)
  Expanded
C07535 -> (196+405) => (1543,1545)
Class
nt06227 Nuclear receptor signaling
Type
Env factor
Pathway
hsa05207  Chemical carcinogenesis - receptor activation
Disease
H00048  Hepatocellular carcinoma
H00014  Non-small cell lung cancer
Gene
196  AHR; aryl hydrocarbon receptor
405  ARNT; aryl hydrocarbon receptor nuclear translocator
1543  CYP1A1; cytochrome P450 family 1 subfamily A member 1
1545  CYP1B1; cytochrome P450 family 1 subfamily B member 1
Perturbant
C07535 (BaP)  Benzo[a]pyrene
Reference
  Authors
Shimizu Y, Nakatsuru Y, Ichinose M, Takahashi Y, Kume H, Mimura J, Fujii-Kuriyama Y, Ishikawa T
  Title
Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor.
  Journal
Proc Natl Acad Sci U S A 97:779-82 (2000)
DOI:10.1073/pnas.97.2.779
Reference
  Authors
Luch A.
  Title
Nature and nurture - lessons from chemical carcinogenesis.
  Journal
Nat Rev Cancer 5:113-25 (2005)
DOI:10.1038/nrc1546
Reference
  Authors
Hidaka T, Fujimura T, Aiba S
  Title
Aryl Hydrocarbon Receptor Modulates Carcinogenesis and Maintenance of Skin Cancers.
  Journal
Front Med (Lausanne) 6:194 (2019)
DOI:10.3389/fmed.2019.00194
Reference
  Authors
Shi S, Yoon DY, Hodge-Bell KC, Bebenek IG, Whitekus MJ, Zhang R, Cochran AJ, Huerta-Yepez S, Yim SH, Gonzalez FJ, Jaiswal AK, Hankinson O
  Title
The aryl hydrocarbon receptor nuclear translocator (Arnt) is required for tumor initiation by benzo[a]pyrene.
  Journal
Carcinogenesis 30:1957-61 (2009)
DOI:10.1093/carcin/bgp201
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