| Entry |
|
|---|
| Name |
PCB to Ahr signaling pathway
|
|---|
| Definition |
PCB -> (AHR+ARNT) => (CYP1A1,CYP1B1) |
|---|
| Expanded |
C14573 -> (196+405) => (1543,1545) |
|---|
| Class |
nt06227 Nuclear receptor signaling (cancer)
|
|---|
| Type |
Env factor
|
|---|
| Pathway |
| hsa05207 | Chemical carcinogenesis - receptor activation |
|
|---|
| Disease |
|
|---|
| Gene |
| 196 | AHR; aryl hydrocarbon receptor |
| 405 | ARNT; aryl hydrocarbon receptor nuclear translocator |
| 1543 | CYP1A1; cytochrome P450 family 1 subfamily A member 1 |
| 1545 | CYP1B1; cytochrome P450 family 1 subfamily B member 1 |
|
|---|
| Perturbant |
| C14573 (PCB) | 3,3',4,4',5-Pentachlorobiphenyl |
|
|---|
| Reference |
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|---|
| Authors |
L'Heritier F, Marques M, Fauteux M, Gaudreau L |
|---|
| Title |
Defining molecular sensors to assess long-term effects of pesticides on carcinogenesis. |
|---|
| Journal |
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|---|
| Reference |
|
|---|
| Authors |
Guarnieri T |
|---|
| Title |
Aryl Hydrocarbon Receptor Connects Inflammation to Breast Cancer. |
|---|
| Journal |
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|---|
| Reference |
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|---|
| Authors |
Smith MT, Guyton KZ, Gibbons CF, Fritz JM, Portier CJ, Rusyn I, DeMarini DM, Caldwell JC, Kavlock RJ, Lambert PF, Hecht SS, Bucher JR, Stewart BW, Baan RA, Cogliano VJ, Straif K |
|---|
| Title |
Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis. |
|---|
| Journal |
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|---|
| Reference |
|
|---|
| Authors |
Rodgers KM, Udesky JO, Rudel RA, Brody JG |
|---|
| Title |
Environmental chemicals and breast cancer: An updated review of epidemiological literature informed by biological mechanisms. |
|---|
| Journal |
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|---|
| LinkDB |
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