KEGG   NETWORK: N01368
Entry
N01368                      Network                                

Name
HCB to Ahr signaling pathway
Definition
HCB -> (AHR+ARNT) => CYP1A1
  Expanded
C11042 -> (196+405) => 1543
Class
nt06227 Nuclear receptor signaling
Type
Env factor
Pathway
hsa05207  Chemical carcinogenesis - receptor activation
Disease
H00031  Breast cancer
Gene
196  AHR; aryl hydrocarbon receptor
405  ARNT; aryl hydrocarbon receptor nuclear translocator
1543  CYP1A1; cytochrome P450 family 1 subfamily A member 1
Perturbant
C11042 (HCB)  Hexachlorobenzene
Reference
  Authors
Miret NV, Pontillo CA, Zarate LV, Kleiman de Pisarev D, Cocca C, Randi AS
  Title
Impact of endocrine disruptor hexachlorobenzene on the mammary gland and breast cancer: The story thus far.
  Journal
Environ Res 173:330-341 (2019)
DOI:10.1016/j.envres.2019.03.054
Reference
  Authors
Garcia MA, Pena D, Alvarez L, Cocca C, Pontillo C, Bergoc R, de Pisarev DK, Randi A
  Title
Hexachlorobenzene induces cell proliferation and IGF-I signaling pathway in an estrogen receptor alpha-dependent manner in MCF-7 breast cancer cell line.
  Journal
Toxicol Lett 192:195-205 (2010)
DOI:10.1016/j.toxlet.2009.10.026
Reference
  Authors
Miret N, Pontillo C, Ventura C, Carozzo A, Chiappini F, Kleiman de Pisarev D, Fernandez N, Cocca C, Randi A
  Title
Hexachlorobenzene modulates the crosstalk between the aryl hydrocarbon receptor and transforming growth factor-beta1 signaling, enhancing human breast cancer cell migration and invasion.
  Journal
Toxicology 366-367:20-31 (2016)
DOI:10.1016/j.tox.2016.08.007
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