| Entry |
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| Name |
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| Definition |
MeIQx -- CYP1A2 >> NAT2 -> N-Acetoxy-MeIQx == DNA |
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| Expanded |
C19255 -- 1544 >> 10 -> C20293 == C00039 |
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| Class |
nt06250 DNA adduct formation (cancer)
|
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| Type |
Env factor
|
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| Pathway |
| hsa05204 | Chemical carcinogenesis - DNA adducts |
|
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| Disease |
| H00014 | Non-small cell lung cancer |
|
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| Gene |
| 1544 | CYP1A2; cytochrome P450 family 1 subfamily A member 2 |
| 10 | NAT2; N-acetyltransferase 2 |
|
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| Perturbant |
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| Metabolite |
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| Reference |
|
|---|
| Authors |
Solomon MS, Morgenthaler PM, Turesky RJ, Essigmann JM |
|---|
| Title |
Mutational and DNA binding specificity of the carcinogen 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline. |
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| Journal |
|
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| Reference |
|
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| Authors |
Nauwelaers G, Bessette EE, Gu D, Tang Y, Rageul J, Fessard V, Yuan JM, Yu MC, Langouet S, Turesky RJ |
|---|
| Title |
DNA adduct formation of 4-aminobiphenyl and heterocyclic aromatic amines in human hepatocytes. |
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| Journal |
|
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| Reference |
|
|---|
| Authors |
Turesky RJ, Le Marchand L |
|---|
| Title |
Metabolism and biomarkers of heterocyclic aromatic amines in molecular epidemiology studies: lessons learned from aromatic amines. |
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| Journal |
|
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| Reference |
|
|---|
| Authors |
Abid Z, Cross AJ, Sinha R |
|---|
| Title |
Meat, dairy, and cancer. |
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| Journal |
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| LinkDB |
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