KEGG   NETWORK: N01373
Entry
N01373                      Network                                

Name
MeIQx to DNA adducts
Definition
MeIQx -- CYP1A2 >> NAT2 -> N-Acetoxy-MeIQx -- DNA
  Expanded
C19255 -- 1544 >> 10 -> C20293 -- C00039
Class
nt06250 DNA adduct formation
Type
Env factor
Pathway
hsa05204  Chemical carcinogenesis - DNA adducts
Disease
H00020  Colorectal cancer
H00014  Non-small cell lung cancer
H00013  Small cell lung cancer
H00019  Pancreatic cancer
Gene
1544  CYP1A2; cytochrome P450 family 1 subfamily A member 2
10  NAT2; N-acetyltransferase 2
Perturbant
C19255 (MeIQx)  MeIQx
Metabolite
C20293  N-Acetoxy-MeIQx
C00039  DNA
Reference
PMID:8702479
  Authors
Solomon MS, Morgenthaler PM, Turesky RJ, Essigmann JM
  Title
Mutational and DNA binding specificity of the carcinogen 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline.
  Journal
J Biol Chem 271:18368-74 (1996)
DOI:10.1074/jbc.271.31.18368
Reference
  Authors
Nauwelaers G, Bessette EE, Gu D, Tang Y, Rageul J, Fessard V, Yuan JM, Yu MC, Langouet S, Turesky RJ
  Title
DNA adduct formation of 4-aminobiphenyl and heterocyclic aromatic amines in human hepatocytes.
  Journal
Chem Res Toxicol 24:913-25 (2011)
DOI:10.1021/tx200091y
Reference
  Authors
Turesky RJ, Le Marchand L
  Title
Metabolism and biomarkers of heterocyclic aromatic amines in molecular epidemiology studies: lessons learned from aromatic amines.
  Journal
Chem Res Toxicol 24:1169-214 (2011)
DOI:10.1021/tx200135s
Reference
  Authors
Abid Z, Cross AJ, Sinha R
  Title
Meat, dairy, and cancer.
  Journal
Am J Clin Nutr 100 Suppl 1:386S-93S (2014)
DOI:10.3945/ajcn.113.071597
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