KEGG   NETWORK: N01380
Entry
N01380                      Network                                
Name
NNK to DNA adducts
Definition
NNK -- (CYP2A6,CYP2A13) -> C19566 -> C19568 -> C20302 == DNA
  Expanded
C16453 -- (1548,1553) -> C19566 -> C19568 -> C20302 == C00039
Class
nt06250 DNA adduct formation (cancer)
Type
Env factor
Pathway
hsa05204  Chemical carcinogenesis - DNA adducts
Disease
H00014  Non-small cell lung cancer
H00013  Small cell lung cancer
Gene
1548  CYP2A6; cytochrome P450 family 2 subfamily A member 6
1553  CYP2A13; cytochrome P450 family 2 subfamily A member 13
Perturbant
C16453 (NNK)  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
Metabolite
C19566  4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone
C19568  N-Nitrosomethanamine
C20302  Methyldiazonium ion
C00039  DNA
Reference
PMID:21473878
  Authors
Chiang HC, Wang CY, Lee HL, Tsou TC
  Title
Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.
  Journal
Toxicol Appl Pharmacol 253:145-52 (2011)
DOI:10.1016/j.taap.2011.03.022
Reference
PMID:20159989
  Authors
Maertens LA, Upadhyaya P, Hecht SS, Zimmerman CL
  Title
Formation and distribution of NNK metabolites in an isolated perfused rat lung.
  Journal
Drug Metab Dispos 38:752-60 (2010)
DOI:10.1124/dmd.109.031492
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