| Entry |
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| Name |
Double-strand break signaling
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| Definition |
MRN == ATM == H2AX -> MRN+ATM+MDC1+H2AX == RNF8+HERC2+UBE2V2+UBE2N -> MRN+ATM+RNF8+MDC1+H2AX == L3MBTL2 == RNF168+UBE2V2+UBE2N+HERC2 == PIAS4 |
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| Expanded |
4361+10111+4683 == 472 == 3014 -> 4361+10111+4683+472+9656+3014 == 9025+8924+7336+7334 -> 4361+10111+4683+472+9025+9656+3014 == 83746 == 165918+7336+7334+8924 == 51588 |
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| Class |
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| Type |
Reference
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| Pathway |
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| Gene |
| 4361 | MRE11; MRE11 homolog, double strand break repair nuclease |
| 10111 | RAD50; RAD50 double strand break repair protein |
| 472 | ATM; ATM serine/threonine kinase |
| 3014 | H2AX; H2A.X variant histone |
| 9656 | MDC1; mediator of DNA damage checkpoint 1 |
| 9025 | RNF8; ring finger protein 8 |
| 8924 | HERC2; HECT and RLD domain containing E3 ubiquitin protein ligase 2 |
| 7336 | UBE2V2; ubiquitin conjugating enzyme E2 V2 |
| 7334 | UBE2N; ubiquitin conjugating enzyme E2 N |
| 83746 | L3MBTL2; L3MBTL histone methyl-lysine binding protein 2 |
| 165918 | RNF168; ring finger protein 168 |
| 51588 | PIAS4; protein inhibitor of activated STAT 4 |
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| Reference |
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| Authors |
Mota MBS, Carvalho MA, Monteiro ANA, Mesquita RD |
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| Title |
DNA damage response and repair in perspective: Aedes aegypti, Drosophila melanogaster and Homo sapiens. |
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| Journal |
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| Reference |
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| Authors |
Kelliher J, Ghosal G, Leung JWC |
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| Title |
New answers to the old RIDDLE: RNF168 and the DNA damage response pathway. |
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| Journal |
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| Reference |
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| Authors |
Schwertman P, Bekker-Jensen S, Mailand N |
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| Title |
Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers. |
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| Journal |
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| LinkDB |
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