KEGG   Homo sapiens (human): 10111
Entry
10111             CDS       T01001                                 
Symbol
RAD50, NBSLD, RAD502, hRad50
Name
(RefSeq) RAD50 double strand break repair protein
  KO
K10866  DNA repair protein RAD50 [EC:3.6.-.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03440  Homologous recombination
hsa03450  Non-homologous end-joining
hsa04218  Cellular senescence
Network
nt06506  Double-strand break repair
  Element
N01439  Double-strand break signaling
N01446  DNA end resection and RPA loading
Disease
H01344  Nijmegen breakage syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03440 Homologous recombination
    10111 (RAD50)
   03450 Non-homologous end-joining
    10111 (RAD50)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:hsa03032]
    10111 (RAD50)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    10111 (RAD50)
DNA replication proteins [BR:hsa03032]
 Eukaryotic type
  DNA Replication Termination Factors
   MRN complex
    10111 (RAD50)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    MRN(MRX) complex
     10111 (RAD50)
    BRCA1-C complex
     10111 (RAD50)
   NHEJ (non-homologous end-joining)
    MRX complex
     10111 (RAD50)
SSDB
Motif
Pfam: AAA_23 Rad50_zn_hook AAA_21 SbcC_Walker_B SMC_N AAA_15 ABC_tran AAA_29 DUF2703
Other DBs
NCBI-GeneID: 10111
NCBI-ProteinID: NP_005723
OMIM: 604040
HGNC: 9816
Ensembl: ENSG00000113522
UniProt: Q92878 A5D6Y3
Structure
LinkDB
Position
5:132556977..132646349
AA seq 1312 aa
MSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPG
TKGNTFVHDPKVAQETDVRAQIRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVITR
TKHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIF
SATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEI
VKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGT
DEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRH
QEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAE
KETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQE
LIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEM
LTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKE
LASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLA
GATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELK
KKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMP
EEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLD
TVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQS
LYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKD
IENYIQDGKDDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQD
NLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKG
YEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKM
EEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLKGDTALDMRGR
CSAGQKVLASLIIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQR
NFQLLVITHDEDFVELLGRSEYVEKFYRIKKNIDQCSEIVKCSVSSLGFNVH
NT seq 3939 nt   +upstreamnt  +downstreamnt
atgtcccggatcgaaaagatgagcattctgggcgtgcggagttttggaatagaggacaaa
gataagcaaattatcactttcttcagcccccttacaattttggttggacccaatggggcg
ggaaagacgaccatcattgaatgtctaaaatatatttgtactggagatttccctcctgga
accaaaggaaatacatttgtacacgatcccaaggttgctcaagaaacagatgtgagagcc
cagattcgtctgcaatttcgtgatgtcaatggagaacttatagctgtgcaaagatctatg
gtgtgtactcagaaaagcaaaaagacagaatttaaaactctggaaggagtcattactaga
acaaagcatggtgaaaaggtcagtctgagctctaagtgtgcagaaattgaccgagaaatg
atcagttctcttggggtttccaaggctgtgctaaataatgtcattttctgtcatcaagaa
gattctaattggcctttaagtgaaggaaaggctttgaagcaaaagtttgatgagattttt
tcagcaacaagatacattaaagccttagaaacacttcggcaggtacgtcagacacaaggt
cagaaagtaaaagaatatcaaatggaactaaaatatctgaagcaatataaggaaaaagct
tgtgagattcgtgatcagattacaagtaaggaagcccagttaacatcttcaaaggaaatt
gtcaaatcctatgagaatgaacttgatccattgaagaatcgtctaaaagaaattgaacat
aatctctctaaaataatgaaacttgacaatgaaattaaagccttggatagccgaaagaag
caaatggagaaagataatagtgaactggaagagaaaatggaaaaggtttttcaagggact
gatgagcaactaaatgacttatatcacaatcaccagagaacagtaagggagaaagaaagg
aaattggtagactgtcatcgtgaactggaaaaactaaataaagaatctaggcttctcaat
caggaaaaatcagaactgcttgttgaacagggtcgtctacagctgcaagcagatcgccat
caagaacatatccgagctagagattcattaattcagtctttggcaacacagctagaattg
gatggctttgagcgtggaccattcagtgaaagacagattaaaaattttcacaaacttgtg
agagagagacaagaaggggaagcaaaaactgccaaccaactgatgaatgactttgcagaa
aaagagactctgaaacaaaaacagatagatgagataagagataagaaaactggactggga
agaataattgagttaaaatcagaaatcctaagtaagaagcagaatgagctgaaaaatgtg
aagtatgaattacagcagttggaaggatcttcagacaggattcttgaactggaccaggag
ctcataaaagctgaacgtgagttaagcaaggctgagaaaaacagcaatgtagaaacctta
aaaatggaagtaataagtctccaaaatgaaaaagcagacttagacaggaccctgcgtaaa
cttgaccaggagatggagcagttaaaccatcatacaacaacacgtacccaaatggagatg
ctgaccaaagacaaagctgacaaagatgaacaaatcagaaaaataaaatctaggcacagt
gatgaattaacctcactgttgggatattttcccaacaaaaaacagcttgaagactggcta
catagtaaatcaaaagaaattaatcagaccagggacagacttgccaaattgaacaaggaa
ctagcttcatctgagcagaataaaaatcatataaataatgaactaaaaagaaaggaagag
cagttgtccagttacgaagacaagctgtttgatgtttgtggtagccaggattttgaaagt
gatttagacaggcttaaagaggaaattgaaaaatcatcaaaacagcgagccatgctggct
ggagccacagcagtttactcccagttcattactcagctaacagacgaaaaccagtcatgt
tgccccgtttgtcagagagtttttcagacagaggctgagttacaagaagtcatcagtgat
ttgcagtctaaactgcgacttgctccagataaactcaagtcaacagaatcagagctaaaa
aaaaaggaaaagcggcgtgatgaaatgctgggacttgtgcccatgaggcaaagcataatt
gatttgaaggagaaggaaataccagaattaagaaacaaactgcagaatgtcaatagagac
atacagcgcctaaagaacgacatagaagaacaagaaacactcttgggtacaataatgcct
gaagaagaaagtgccaaagtatgcctgacagatgttacaattatggagaggttccagatg
gaacttaaagatgttgaaagaaaaattgcacaacaagcagctaagctacaaggaatagac
ttagatcgaactgtccaacaagtcaaccaggagaaacaagagaaacagcacaagttagac
acagtttctagtaagattgaattgaatcgtaagcttatacaggaccagcaggaacagatt
caacatctaaaaagtacaacaaatgagctaaaatctgagaaacttcagatatccactaat
ttgcaacgtcgtcagcaactggaggagcagactgtggaattatccactgaagttcagtct
ttgtacagagagataaaggatgctaaagagcaggtaagccctttggaaacaacattggaa
aagttccagcaagaaaaagaagaattaatcaacaaaaaaaatacaagcaacaaaatagca
caggataaactgaatgatattaaagagaaggttaaaaatattcatggctatatgaaagac
attgagaattatattcaagatgggaaagacgactataagaagcaaaaagaaactgaactt
aataaagtaatagctcaactaagtgaatgcgagaaacacaaagaaaagataaatgaagat
atgagactcatgagacaagatattgatacacagaagatacaagaaaggtggctacaagat
aaccttactttaagaaaaagaaatgaggaactaaaagaagttgaagaagaaagaaaacaa
catttgaaggaaatgggtcaaatgcaggttttgcaaatgaaaagtgaacatcagaagttg
gaagagaacatagacaatataaaaagaaatcataatttggcattagggcgacagaaaggt
tatgaagaagaaattattcattttaagaaagaacttcgagaaccacaatttcgggatgct
gaggaaaagtatagagaaatgatgattgttatgaggacaacagaacttgtgaacaaggat
ctggatatttattataagactcttgaccaagcaataatgaaatttcacagtatgaaaatg
gaagaaatcaataaaattatacgtgacctgtggcgaagtacctatcgtggacaagatatt
gaatacatagaaatacggtctgatgccgatgaaaatgtatcagcttctgataaaaggcgg
aattataactaccgagtggtgatgctgaagggagacacagccttggatatgcgaggacga
tgcagtgctggacaaaaggtattagcctcactcatcattcgcctggccctggctgaaacg
ttctgcctcaactgtggcatcattgccttggatgagccaacaacaaatcttgaccgagaa
aacattgaatctcttgcacatgctctggttgagataataaaaagtcgctcacagcagcgt
aacttccagcttctggtaatcactcatgatgaagattttgtggagcttttaggacgttct
gaatatgtggagaaattctacaggattaaaaagaacatcgatcagtgctcagagattgtg
aaatgcagtgttagctccctgggattcaatgttcattaa

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