Homo sapiens (human): 4361
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Entry
4361 CDS
T01001
Symbol
MRE11, ATLD, HNGS1, MRE11A, MRE11B
Name
(RefSeq) MRE11 homolog, double strand break repair nuclease
KO
K10865
double-strand break repair protein MRE11
Organism
hsa
Homo sapiens (human)
Pathway
hsa03440
Homologous recombination
hsa03450
Non-homologous end-joining
hsa04218
Cellular senescence
Network
nt06506
Double-strand break repair
Element
N01439
Double-strand break signaling
N01446
DNA end resection and RPA loading
Disease
H00094
Immunodeficiency associated with DNA repair defects
H02014
Ataxia-telangiectasia-like syndrome
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09120 Genetic Information Processing
09124 Replication and repair
03440 Homologous recombination
4361 (MRE11)
03450 Non-homologous end-joining
4361 (MRE11)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03032 DNA replication proteins [BR:
hsa03032
]
4361 (MRE11)
03400 DNA repair and recombination proteins [BR:
hsa03400
]
4361 (MRE11)
DNA replication proteins [BR:
hsa03032
]
Eukaryotic type
DNA Replication Termination Factors
MRN complex
4361 (MRE11)
DNA repair and recombination proteins [BR:
hsa03400
]
Eukaryotic type
DSBR (double strand breaks repair)
HR (homologous recombination)
MRN(MRX) complex
4361 (MRE11)
BRCA1-C complex
4361 (MRE11)
NHEJ (non-homologous end-joining)
MRX complex
4361 (MRE11)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Mre11_DNA_bind
Metallophos
Motif
Other DBs
NCBI-GeneID:
4361
NCBI-ProteinID:
NP_005582
OMIM:
600814
HGNC:
7230
Ensembl:
ENSG00000020922
UniProt:
P49959
Structure
PDB
PDBj
LinkDB
All DBs
Position
11:complement(94415570..94512412)
Genome browser
AA seq
708 aa
AA seq
DB search
MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGD
LFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISI
PVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYG
LGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDL
VIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIP
LHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEK
PLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITK
PSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEK
TQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAF
SADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLE
TSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTS
KTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR
NT seq
2127 nt
NT seq
+upstream
nt +downstream
nt
atgagtactgcagatgcacttgatgatgaaaacacatttaaaatattagttgcaacagat
attcatcttggatttatggagaaagatgcagtcagaggaaatgatacgtttgtaacactc
gatgaaattttaagacttgcccaggaaaatgaagtggattttattttgttaggtggtgat
ctttttcatgaaaataagccctcaaggaaaacattacatacctgcctcgagttattaaga
aaatattgtatgggtgatcggcctgtccagtttgaaattctcagtgatcagtcagtcaac
tttggttttagtaagtttccatgggtgaactatcaagatggcaacctcaacatttcaatt
ccagtgtttagtattcatggcaatcatgacgatcccacaggggcagatgcactttgtgcc
ttggacattttaagttgtgctggatttgtaaatcactttggacgttcaatgtctgtggag
aagatagacattagtccggttttgcttcaaaaaggaagcacaaagattgcgctatatggt
ttaggatccattccagatgaaaggctctatcgaatgtttgtcaataaaaaagtaacaatg
ttgagaccaaaggaagatgagaactcttggtttaacttatttgtgattcatcagaacagg
agtaaacatggaagtactaacttcattccagaacaatttttggatgacttcattgatctt
gttatctggggccatgaacatgagtgtaaaatagctccaaccaaaaatgaacaacagctg
ttttatatctcacaacctggaagctcagtggttacttctctttccccaggagaagctgta
aagaaacatgttggtttgctgcgtattaaagggaggaagatgaatatgcataaaattcct
cttcacacagtgcggcagtttttcatggaggatattgttctagctaatcatccagacatt
tttaacccagataatcctaaagtaacccaagccatacaaagcttctgtttggagaagatt
gaagaaatgcttgaaaatgctgaacgggaacgtctgggtaattctcaccagccagagaag
cctcttgtacgactgcgagtggactatagtggaggttttgaacctttcagtgttcttcgc
tttagccagaaatttgtggatcgggtagctaatccaaaagacattatccattttttcagg
catagagaacaaaaggaaaaaacaggagaagagatcaactttgggaaacttatcacaaag
ccttcagaaggaacaactttaagggtagaagatcttgtaaaacagtactttcaaaccgca
gagaagaatgtgcagctctcactgctaacagaaagagggatgggtgaagcagtacaagaa
tttgtggacaaggaggagaaagatgccattgaggaattagtgaaataccagttggaaaaa
acacagcgatttcttaaagaacgtcatattgatgccctcgaagacaaaatcgatgaggag
gtacgtcgtttcagagaaaccagacaaaaaaatactaatgaagaagatgatgaagtccgt
gaggctatgaccagggccagagcactcagatctcagtcagaggagtctgcttctgccttt
agtgctgatgaccttatgagtatagatttagcagaacagatggctaatgactctgatgat
agcatctcagcagcaaccaacaaaggaagaggccgaggaagaggtcgaagaggtggaaga
gggcagaattcagcatcgagaggagggtctcaaagaggaagagcagacactggtctggag
acttctacccgtagcaggaactcaaagactgctgtgtcagcatctagaaatatgtctatt
atagatgcctttaaatctacaagacagcagccttcccgaaatgtcactactaagaattat
tcagaggtgattgaggtagatgaatcagatgtggaagaagacatttttcctaccacttca
aagacagatcaaaggtggtccagcacatcatccagcaaaatcatgtcccagagtcaagta
tcgaaaggggttgattttgaatcaagtgaggatgatgatgatgatccttttatgaacact
agttctttaagaagaaatagaagataa
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