KEGG   NETWORK: N01494
Entry
N01494                      Network                                
Name
Alternative pathway of complement cascade, C3/5 convertase formation
Definition
C3 -- ((C3H2O+Bb),(C3b+Bb)) -> C3b -> (C3b+CFB) -- CFD -> (C3b+Bb) -> ((C3b+Bb)+CFP) -> ((C3b+Bb+C3b)+CFP)
  Expanded
718 -- ((C22539+C22540),(C22533+C22540)) -> C22533 -> (C22533+629) -- 1675 -> (C22533+C22540) -> ((C22533+C22540)+5199) -> ((C22533+C22540+C22533)+5199)
Class
nt06513 Complement cascade
Type
Reference
Pathway
hsa04610  Complement and coagulation cascades
Gene
718  C3; complement C3
629  CFB; complement factor B
1675  CFD; complement factor D
5199  CFP; complement factor properdin
Metabolite
C22539  Complement C3(H2O)
C22533  Complement component 3b
C22540  Complement factor Bb
Reference
PMID:26082779
  Authors
Merle NS, Church SE, Fremeaux-Bacchi V, Roumenina LT
  Title
Complement System Part I - Molecular Mechanisms of Activation and Regulation.
  Journal
Front Immunol 6:262 (2015)
DOI:10.3389/fimmu.2015.00262
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