KEGG   NETWORK: N01554
Entry
N01554                      Network                                
Name
IL2 family to Jak-STAT signaling pathway
Definition
(IL2,IL4,IL7,IL9,IL15,IL21,TSLP) -> ((IL2RG+IL2RB+(IL2RA,IL15RA),(IL2RG+(IL4R,IL7R,IL9R,IL21R),(IL7R+CRLF2)) -> (JAK1+JAK3) -> (STAT1,STAT3,STAT5,STAT6)
  Expanded
(3558,3565,3574,3578,3600,59067,85480) -> ((3561+3560+(3559,3601),(3561+(3566,3575,3581,50615),(3575+64109)) -> (3716+3718) -> (6772,6774,(6776,6777),6778)
Class
nt06518 JAK-STAT signaling
Type
Reference
Pathway
hsa04630  JAK-STAT signaling pathway
Gene
3558  IL2; interleukin 2
3565  IL4; interleukin 4
3574  IL7; interleukin 7
3578  IL9; interleukin 9
3600  IL15; interleukin 15
59067  IL21; interleukin 21
85480  TSLP; thymic stromal lymphopoietin
3561  IL2RG; interleukin 2 receptor subunit gamma
3560  IL2RB; interleukin 2 receptor subunit beta
3559  IL2RA; interleukin 2 receptor subunit alpha
3601  IL15RA; interleukin 15 receptor subunit alpha
3566  IL4R; interleukin 4 receptor
3575  IL7R; interleukin 7 receptor
3581  IL9R; interleukin 9 receptor
50615  IL21R; interleukin 21 receptor
64109  CRLF2; cytokine receptor like factor 2
3716  JAK1; Janus kinase 1
3718  JAK3; Janus kinase 3
6772  STAT1; signal transducer and activator of transcription 1
6774  STAT3; signal transducer and activator of transcription 3
6776  STAT5A; signal transducer and activator of transcription 5A
6777  STAT5B; signal transducer and activator of transcription 5B
6778  STAT6; signal transducer and activator of transcription 6
Reference
PMID:30267440
  Authors
Morris R, Kershaw NJ, Babon JJ
  Title
The molecular details of cytokine signaling via the JAK/STAT pathway.
  Journal
Protein Sci 27:1984-2009 (2018)
DOI:10.1002/pro.3519
Reference
PMID:32203403
  Authors
Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
  Title
JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
  Journal
Nat Rev Gastroenterol Hepatol 17:323-337 (2020)
DOI:10.1038/s41575-020-0273-0
Reference
PMID:34492272
  Authors
Tzeng HT, Chyuan IT, Lai JH
  Title
Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
  Journal
Biochem Pharmacol 193:114760 (2021)
DOI:10.1016/j.bcp.2021.114760
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