KEGG   NETWORK: N01557
Entry
N01557                      Network                                
Name
IL12/23 to Jak-STAT signaling pathway
Definition
(IL12,IL23A) -> ((IL12RB1+IL12RB2),(IL12RB1+IL23R)) -> (JAK2+TYK2) -> (STAT3,STAT4)
  Expanded
((3592,3593),51561) -> ((3594+3595),(3594+149233)) -> (3717+7297) -> (6774,6775)
Class
nt06518 JAK-STAT signaling
Type
Reference
Pathway
hsa04630  JAK-STAT signaling pathway
Gene
3592  IL12A; interleukin 12A
3593  IL12B; interleukin 12B
51561  IL23A; interleukin 23 subunit alpha
3594  IL12RB1; interleukin 12 receptor subunit beta 1
3595  IL12RB2; interleukin 12 receptor subunit beta 2
149233  IL23R; interleukin 23 receptor
3717  JAK2; Janus kinase 2
7297  TYK2; tyrosine kinase 2
6774  STAT3; signal transducer and activator of transcription 3
6775  STAT4; signal transducer and activator of transcription 4
Reference
PMID:30267440
  Authors
Morris R, Kershaw NJ, Babon JJ
  Title
The molecular details of cytokine signaling via the JAK/STAT pathway.
  Journal
Protein Sci 27:1984-2009 (2018)
DOI:10.1002/pro.3519
Reference
PMID:32203403
  Authors
Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
  Title
JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
  Journal
Nat Rev Gastroenterol Hepatol 17:323-337 (2020)
DOI:10.1038/s41575-020-0273-0
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