| Entry |
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| Name |
Regulation of NLRP3 inflammasome signaling pathway, NLRP3 inhibition
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| Definition |
(CARD8,GPSM3,IRGM,NO) -| (NLRP3+PYCARD) |
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| Expanded |
(22900,63940,345611,C00533) -| (114548+29108) |
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| Class |
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| Type |
Reference
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| Pathway |
| hsa04621 | NOD-like receptor signaling pathway |
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| Gene |
| 22900 | CARD8; caspase recruitment domain family member 8 |
| 63940 | GPSM3; G protein signaling modulator 3 |
| 345611 | IRGM; immunity related GTPase M |
| 114548 | NLRP3; NLR family pyrin domain containing 3 |
| 29108 | PYCARD; PYD and CARD domain containing |
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| Metabolite |
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| Reference |
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| Authors |
Jo EK, Kim JK, Shin DM, Sasakawa C |
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| Title |
Molecular mechanisms regulating NLRP3 inflammasome activation. |
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| Journal |
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| Reference |
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| Authors |
Ito S, Hara Y, Kubota T |
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| Title |
CARD8 is a negative regulator for NLRP3 inflammasome, but mutant NLRP3 in cryopyrin-associated periodic syndromes escapes the restriction. |
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| Journal |
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| Reference |
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| Authors |
Mehto S, Jena KK, Nath P, Chauhan S, Kolapalli SP, Das SK, Sahoo PK, Jain A, Taylor GA, Chauhan S |
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| Title |
The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy. |
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| Journal |
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| LinkDB |
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