Homo sapiens (human): 22900
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Entry
22900 CDS
T01001
Symbol
CARD8, CARDINAL, DACAR, DAKAR, NDPP, NDPP1, TUCAN
Name
(RefSeq) caspase recruitment domain family member 8
KO
K12801
caspase recruitment domain-containing protein 8
Organism
hsa
Homo sapiens (human)
Pathway
hsa04621
NOD-like receptor signaling pathway
Network
nt06521
NLR signaling
Element
N01568
Regulation of NLRP3 inflammasome signaling pathway, NLRP3 inhibition
Disease
H01227
Inflammatory bowel disease (IBD)
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09151 Immune system
04621 NOD-like receptor signaling pathway
22900 (CARD8)
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Gene cluster
GFIT
Motif
Pfam:
FIIND
CARD
Motif
Other DBs
NCBI-GeneID:
22900
NCBI-ProteinID:
NP_001171829
OMIM:
609051
HGNC:
17057
Ensembl:
ENSG00000105483
Pharos:
Q9Y2G2
(Tbio)
UniProt:
Q9Y2G2
Structure
PDB
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All DBs
Position
19:complement(48179825..48255946)
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AA seq
537 aa
AA seq
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MEKKECPEKSSSSEEELPRRDSGSSRNIDASKLIRLQGSRKLLVDNSIRELQYTKTGIFF
QAEACVTNDTVYRELPCVSETLCDISHFFQEDDETEAEPLLFRAVPECQLSGGDIPSVSE
EQESSEGQDSGDICSEENQIVSSYASKVCFEIEEDYKNRQFLGPEGNVDVELIDKSTNRY
SVWFPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLALDLQHHEQWLVGGPLFDVTAE
PEEAVAEIHLPHFISLQAGEVDVSWFLVAHFKNEGMVLEHPARVEPFYAVLESPSFSLMG
ILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSDALLTKAIDDEEDRFHGVRLQ
TSPPMEPLNFGSSYIVSNSANLKVMPKELKLSYRSPGEIQHFSKFYAGQMKEPIQLEITE
KRHGTLVWDTEVKPVDLQLVAASAPPPFSGAAFVKENHRQLQARMGDLKGVLDDLQDNEV
LTENEKELVEQEKTRQSKNEALLSMVEKKGDLALDVLFRSISERDPYLVSYLRQQNL
NT seq
1614 nt
NT seq
+upstream
nt +downstream
nt
atggaaaaaaaggagtgtccagaaaagagtagcagcagtgaggaagagctgccgagacgg
gacagtggatccagtaggaacatagatgcatccaaactcattagactacaaggatcacgg
aaactgttggttgacaatagcatacgggaactgcaatacacaaaaactggaatttttttt
caggctgaggcctgtgtgacaaatgatacggtatacagggagctaccctgtgtttctgag
accctttgtgacatctcacattttttccaagaagatgatgagacagaggcagagccatta
ttgttccgtgctgttcctgagtgtcaactatctgggggggacattcccagtgtatcagaa
gagcaggaatcttcagagggacaagattcaggagacatttgctcagaagagaatcaaata
gtttcctcttatgcttctaaagtctgttttgagatcgaagaagattataaaaatcgtcag
tttctggggcctgaaggaaatgtggatgttgagttgattgataagagcacaaacagatac
agcgtttggttccccactgctggctggtatctgtggtcagccacaggcctcggcttcctg
gtaagggatgaggtcacagtgacgattgcgtttggttcctggagtcagcacctggccctg
gacctgcagcaccatgaacagtggctggtgggcggccccttgtttgatgtcactgcagag
ccagaggaggctgtcgccgaaatccacctcccccacttcatctccctccaagcaggtgag
gtggacgtctcctggtttctcgttgcccattttaagaatgaagggatggtcctggagcat
ccagcccgggtggagcctttctatgctgtcctggaaagccccagcttctctctgatgggc
atcctgctgcggatcgccagtgggactcgcctctccatccccatcacttccaacacattg
atctattatcacccccaccccgaagatattaagttccacttgtaccttgtccccagcgac
gccttgctaacaaaggcgatagatgatgaggaagatcgcttccatggtgtgcgcctgcag
acttcgcccccaatggaacccctgaactttggttccagttatattgtgtctaattctgct
aacctgaaagtaatgcccaaggagttgaaattgtcctacaggagccctggagaaattcag
cacttctcaaaattctatgctgggcagatgaaggaacccattcaacttgagattactgaa
aaaagacatgggactttggtgtgggatactgaggtgaagccagtggatctccagcttgta
gctgcatcagcccctcctcctttctcaggtgcagcctttgtgaaggagaaccaccggcaa
ctccaagccaggatgggggacctgaaaggggtgctcgatgatctccaagacaatgaggtt
cttactgagaatgagaaggagctggtggagcaggaaaagacacggcagagcaagaatgag
gccttgctgagcatggtggagaagaaaggggacctggccctggacgtgctcttcagaagc
attagtgaaagggacccttacctcgtgtcctatcttagacagcagaatttgtaa
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