KEGG NETWORK: N01578

NETWORK: N01578

Entry

N01578                      Network

Name

GATOR1-mTORC1 signaling pathway

Definition

(NPRL2/3+DEPDC5) -| RRAGA/B/C/D -> mTORC1

Expanded

(10641+8131+9681) -| (10670+10325+64121+58528) -> (2475+57521+84335+64798+64223+9894+9675)

Class

nt06522 mTOR signaling

Type

Reference

Pathway

hsa04150

mTOR signaling pathway

Gene

10641

NPRL2; NPR2 like, GATOR1 complex subunit

8131	NPRL3; NPR3 like, GATOR1 complex subunit

9681	DEPDC5; DEP domain containing 5, GATOR1 subcomplex subunit

10670

RRAGA; Ras related GTP binding A

10325

RRAGB; Ras related GTP binding B

64121

RRAGC; Ras related GTP binding C

58528

RRAGD; Ras related GTP binding D

2475	MTOR; mechanistic target of rapamycin kinase

57521

RPTOR; regulatory associated protein of MTOR complex 1

84335

AKT1S1; AKT1 substrate 1

64798

DEPTOR; DEP domain containing MTOR interacting protein

64223

MLST8; MTOR associated protein, LST8 homolog

9894	TELO2; telomere maintenance 2

9675	TTI1; TELO2 interacting protein 1

Reference

PMID:19812304

Authors

Laplante M, Sabatini DM

Title

mTOR signaling at a glance.

Journal

J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011

Reference

PMID:27173016

Authors

Weckhuysen S, Marsan E, Lambrecq V, Marchal C, Morin-Brureau M, An-Gourfinkel I, Baulac M, Fohlen M, Kallay Zetchi C, Seeck M, de la Grange P, Dermaut B, Meurs A, Thomas P, Chassoux F, Leguern E, Picard F, Baulac S

Title

Involvement of GATOR complex genes in familial focal epilepsies and focal cortical dysplasia.

Journal

Epilepsia 57:994-1003 (2016)
DOI:10.1111/epi.13391

Reference

PMID:29359340

Authors

Marsan E, Baulac S

Title

Review: Mechanistic target of rapamycin (mTOR) pathway, focal cortical dysplasia and epilepsy.

Journal

Neuropathol Appl Neurobiol 44:6-17 (2018)
DOI:10.1111/nan.12463

LinkDB

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