Homo sapiens (human): 9681
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Entry
9681 CDS
T01001
Symbol
DEPDC5, DEE111, DEP.5, FFEVF, FFEVF1, FPEVF
Name
(RefSeq) DEP domain containing 5, GATOR1 subcomplex subunit
KO
K20404
SEA/GATOR complex protein SEA1/DEPDC5
Organism
hsa
Homo sapiens (human)
Pathway
hsa04150
mTOR signaling pathway
Network
nt06522
mTOR signaling
Element
N01578
GATOR1-mTORC1 signaling pathway
Disease
H00606
Early infantile epileptic encephalopathy
H02214
Familial focal epilepsy with variable foci
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04150 mTOR signaling pathway
9681 (DEPDC5)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
9681 (DEPDC5)
Membrane trafficking [BR:
hsa04131
]
Autophagy
Other autophagy associated proteins
SEACIT/GATOR1 complex
9681 (DEPDC5)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DEPDC5_CTD
IML1
IML1_N
DEP
FGGY_N
Motif
Other DBs
NCBI-GeneID:
9681
NCBI-ProteinID:
NP_001229825
OMIM:
614191
HGNC:
18423
Ensembl:
ENSG00000100150
UniProt:
O75140
Structure
PDB
PDBj
LinkDB
All DBs
Position
22:31753968..31908033
Genome browser
AA seq
1603 aa
AA seq
DB search
MRTTKVYKLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEIAHPNDEYSPLLLQVKSLKE
DLQKETISVDQTVTQVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLKKS
LVSTCAYITQKVEFAGIRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQMSCE
MWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEINRA
SIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQAEGFPQGDNST
SAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN
GIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQLFCNSFT
PRIKLAGKKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPSRAQCLTT
CRSVRERESHSRKSASSCDVSSSPSLPSRTLPTEEVRSQASDDSSLGKSANILMIPHPHL
HQYEVSSSLGYTSTRDVLENMMEPPQRDSSAPGRFHVGSAESMLHVRPGGYTPQRALINP
FAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQTRQNMAELQGSGQRDPTHSSAELLE
LAYHEAAGRHSNSRQPGDGMSFLNFSGTEELSVGLLSNSGAGMNPRTQNKDSLEDSVSTS
PDPILTLSAPPVVPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPE
ADIDRRDEDGVQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGL
VSRNRPEEEDQYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYSLCPSHSDSE
FVSCWVEFSHERLEEYKWNYLDQYICSAGSEDFSLIESLKFWRTRFLLLPACVTATKRIT
EGEAHCDIYGDRPRADEDEWQLLDGFVRFVEGLNRIRRRHRSDRMMRKGTAMKGLQMTGP
ISTHSLESTAPPVGKKGTSALSALLEMEASQKCLGEQQAAVHGGKSSAQSAESSSVAMTP
TYMDSPRKDGAFFMEFVRSPRTASSAFYPQVSVDQTATPMLDGTSLGICTGQSMDRGNSQ
TFGNSQNIGEQGYSSTNSSDSSSQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGL
SPYCFISAEVVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGEAWRTFIYGFYFYKI
VTDKEPDRVAMQQPATTWHTAGVDDFASFQRKWFEVAFVAEELVHSEIPAFLLPWLPSRP
ASYASRHSSFSRSFGGRSQAAALLAATVPEQRTVTLDVDVNNRTDRLEWCSCYYHGNFSL
NAAFEIKLHWMAVTAAVLFEMVQGWHRKATSCGFLLVPVLEGPFALPSYLYGDPLRAQLF
IPLNISCLLKEGSEHLFDSFEPETYWDRMHLFQEAIAHRFGFVQDKYSASAFNFPAENKP
QYIHVTGTVFLQLPYSKRKFSGQQRRRRNSTSSTNQNMFCEERVGYNWAYNTMLTKTWRS
SATGDEKFADRLLKDFTDFCINRDNRLVTFWTSCLEKMHASAP
NT seq
4812 nt
NT seq
+upstream
nt +downstream
nt
atgagaacaacaaaggtctacaaactcgtcatccacaagaagggctttgggggcagtgat
gatgagctagttgtgaaccccaaagtgttccctcacatcaagcttggagacattgtagag
attgcacaccccaacgatgaatacagccctctgcttttgcaggtcaagtctcttaaggaa
gatttacagaaggaaactatcagtgtggaccagactgtgactcaagtgttccggctgaga
ccttatcaggatgtctatgttaatgtcgtagaccctaaggatgtgacccttgacctagtg
gaattaacttttaaggatcagtatattggccgtggggatatgtggcgactaaagaaaagt
ttggtcagcacatgtgcctatatcacccagaaggtggagtttgctggcatcagagcacag
gctggtgaactgtgggttaagaatgagaaggtcatgtgtggctacatcagtgaagatacc
agggtggtgtttcgttctacgtcggctatggtttacatatttattcagatgagctgtgaa
atgtgggattttgatatttatggggatttgtattttgagaaagctgtgaatggtttcctt
gctgatctatttaccaagtggaaggagaagaactgtagtcatgaagtgacagtggtcctg
ttttctagaactttctatgatgcaaaatctgttgatgaatttcctgaaataaaccgagcc
tcaattcgacaggatcacaaggggagattctatgaagacttttacaaagtggtggtgcag
aatgagagaagagaagaatggacttcacttctcgtaaccattaaaaaactcttcatccag
tatccagtgttggtgcgactggaacaggcagagggctttcctcaaggagataattctacc
tcagcacaaggaaactacctggaggccatcaatctgtcattcaatgtgtttgataagcac
tacatcaaccgcaactttgaccgaactgggcagatgtcagtggtgatcacgcccggggtg
ggtgtctttgaagtggaccgcctactcatgatcctgaccaagcagcggatgatagataat
ggaattggtgtggatttggtgtgcatgggagagcaaccgttacatgctgtcccattgttc
aagctccataatcggagtgctccccgtgattctcgtctgggcgatgactataatatccct
cactggataaaccacagtttctacacatccaaaagccagctcttttgtaatagtttcacc
ccacgaataaaactggcaggaaagaagcccgcctctgagaaagcaaaaaatggccgtgat
acatctctcgggagtccaaaagaatctgagaacgcccttcccatccaagtagattatgac
gcctatgacgctcaagtgttcaggctgcccggcccatcccgggcccagtgcctcaccacc
tgcagatctgtgcgagagcgagagagtcacagtcgaaagagtgccagctcctgtgatgtt
tcatccagcccttccctaccaagccgcacactgcccactgaggaagtgaggagccaggct
tctgacgacagctccctaggcaagagtgccaacatcctgatgatcccacacccccacctg
caccagtatgaagtcagcagctccttgggatacaccagcactcgagatgtcctggagaac
atgatggagccaccacagcgagactccagtgcaccagggaggtttcacgttggcagtgca
gaatccatgctgcatgttcgacctggtggatacacgccccagagagcactgattaacccc
ttcgctccctctcggatgcccatgaagcttacgtccaacagaaggcgctggatgcacact
tttcctgtggggccatccggagaagccatccagatccaccaccagacccgacagaatatg
gcggagctacaaggcagcgggcagagggatccaactcactcctctgcagagctgctggag
ttagcatatcatgaagctgctggaaggcacagcaattcccgccagcctggtgacggcatg
tccttcttgaacttcagtggaacagaggagctttctgtcggcctgcttagcaacagtggt
gcaggtatgaatcctaggacccagaataaggattctctagaggacagtgtttctacctct
ccagacccaattctgacactgtctgctccccctgtagtgccaggcttctgttgcacagtt
ggagtggactggaagtctctcactactccggcgtgcctcccccttaccaccgactacttc
cctgaccgccagggcctgcagaatgactacacagagggctgttatgatctccttccagaa
gcagacatcgacaggagggacgaagatggtgtgcagatgacagcccagcaggtatttgaa
gagtttatttgccaacgtctcatgcagggctaccaaatcatagtgcagcccaagacacag
aaacccaatcctgctgtcccgcccccgctgagcagtagcccactctatagccgaggcctt
gtgtcccgaaaccgccctgaggaggaggaccagtattggctgagtatgggcagaacgttc
cacaaagtgacgctgaaggataagatgatcacagtgacgcgataccttcccaagtatcct
tatgaatctgcccagatccactacacctacagcctctgtccttcccactcagactcagag
ttcgtctcctgctgggtggaattctcccacgaacggctggaggagtacaagtggaattac
ttagatcagtatatctgttctgccggctctgaagacttcagcttaattgagtccctgaag
ttctggaggacccgcttcctgctgctgccagcctgtgtcaccgccaccaagcgcatcacg
gagggggaggcccactgcgacatctatggggacaggccccgtgcagacgaggacgagtgg
caactcctggatggttttgtccgctttgtggagggcttgaatcgcattcgcaggcggcat
cgctcggatcgcatgatgcggaaagggaccgccatgaaaggcttgcagatgactgggccc
atttccacgcattctctggagtcaactgcacccccagtggggaagaagggaacctcagct
ctctctgccctgttggagatggaggccagtcagaagtgcctgggagaacagcaggcagct
gtgcatggtgggaagagctccgcccagtcagccgagagcagcagcgttgccatgactccc
acctacatggacagcccacgaaaggacggggccttctttatggagtttgtccgcagccca
cgcacagcatcgtccgccttctaccctcaggtatctgtggaccaaacagccactcctatg
ttggacggcaccagtttgggcatatgcacaggccaatccatggacagaggcaacagccag
acctttgggaactcccagaacataggagaacagggctactcctccacaaactccagtgac
agcagctctcagcagctggtggcaagctccttgacctcatcctctaccctgacagagatc
ctggaagccatgaagcacccctcgacaggagtccagctgctctctgaacagaagggcctc
tcaccgtactgcttcatcagcgcggaggtggtacactggttggtgaaccacgtggagggg
atccagacacaggcgatggccattgacatcatgcagaaaatgctggaagagcagctcatc
acacatgcatctggcgaagcctggcggaccttcatctacggcttctatttctacaagata
gtaacggacaaagagcccgaccgagtggccatgcagcagcccgccaccacctggcacaca
gcaggagtggacgacttcgccagcttccagcgcaagtggtttgaggtggcctttgtggca
gaagagctcgtgcactctgagattcctgcctttctcctgccctggctgcctagccggcca
gcctcctatgcaagtaggcacagctcctttagccgaagttttggaggacggagccaggcg
gcagcacttttagctgccactgtcccagagcagaggactgtgaccctggatgttgacgtg
aacaaccgcacagaccggctggagtggtgcagctgttattaccatggcaacttttctctg
aatgcagcctttgagatcaagctgcactggatggcggtgaccgcagcagtactcttcgag
atggtccaaggttggcatcggaaagccacctcctgtggcttcttgttagtcccagttttg
gaggggccttttgcactgcccagttacctgtatggcgacccccttcgtgcccagctcttc
atcccactcaacatcagctgcttgctcaaggagggcagcgagcacctgtttgatagcttt
gaacccgaaacgtactgggatcgaatgcacctcttccaggaagccattgcacacaggttt
gggtttgtacaagataaatattctgcctctgcttttaacttccctgctgagaacaagcct
cagtatatccacgttacaggaacagtgtttctgcagctgccctactccaagcgcaagttc
tcagggcagcagcggcggcggcggaactccaccagctccaccaaccagaacatgttctgc
gaggagcgggtcggctacaactgggcctacaacaccatgctcaccaaaacatggcgctcc
agcgccacaggggatgaaaagtttgctgatcggctgctgaaggacttcacggacttctgc
atcaaccgtgacaaccggctggtcacgttctggacaagttgcctggagaagatgcatgcc
agtgccccgtga
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