KEGG   NETWORK: N01587
Entry
N01587                      Network                                
Name
Fe-TF transport
Definition
Fe2+ -- CP -> Fe3+ -- (TF+TFR1) -> Fe3+(endosome) -- STEAP3 -> Fe2+ -- (DMT1,ZIP8/14) -> Fe2+
  Expanded
C14818 -- 1356 -> C14819 -- (7018+7037) -> C14819 -- 55240 -> C14818 -- (4891,23516,64116) -> C14818
Class
nt06525 Ferroptosis
Type
Reference
Pathway
hsa04216  Ferroptosis
Gene
1356  CP; ceruloplasmin
7018  TF; transferrin
7037  TFRC; transferrin receptor
55240  STEAP3; STEAP3 metalloreductase
4891  SLC11A2; solute carrier family 11 member 2
23516  SLC39A14; solute carrier family 39 member 14
64116  SLC39A8; solute carrier family 39 member 8
Metabolite
C14818  Fe2+
C14819  Fe3+
Reference
PMID:28082232
  Authors
Guiney SJ, Adlard PA, Bush AI, Finkelstein DI, Ayton S
  Title
Ferroptosis and cell death mechanisms in Parkinson's disease.
  Journal
Neurochem Int 104:34-48 (2017)
DOI:10.1016/j.neuint.2017.01.004
Reference
PMID:35075250
  Authors
Chen J, Li X, Ge C, Min J, Wang F
  Title
The multifaceted role of ferroptosis in liver disease.
  Journal
Cell Death Differ 29:467-480 (2022)
DOI:10.1038/s41418-022-00941-0
Reference
PMID:35788564
  Authors
Fang X, Ardehali H, Min J, Wang F
  Title
The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease.
  Journal
Nat Rev Cardiol 20:7-23 (2023)
DOI:10.1038/s41569-022-00735-4
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