KEGG   NETWORK: N01639
Entry
N01639                      Network                                
Name
Cardiac-type VGCC-RYR signaling
Definition
Ca2+(extracellular) -- CAV1.2 -> Ca2+(cyto) -> (RYR2+TRDN+JCN+CASQ) -> Ca2+(cyto)
  Expanded
C00076 -- (775+(781,9254,55799,93589)+(782,783,784,785)+(786,10369,10368,27092,27091,59285,59284)) -> C00076 -> (6262+10345+444+(844,845)) -> C00076
Class
nt06528 Calcium signaling
Type
Reference
Pathway
hsa04020  Calcium signaling pathway
Gene
775  CACNA1C; calcium voltage-gated channel subunit alpha1 C
781  CACNA2D1; calcium voltage-gated channel auxiliary subunit alpha2delta 1
9254  CACNA2D2; calcium voltage-gated channel auxiliary subunit alpha2delta 2
55799  CACNA2D3; calcium voltage-gated channel auxiliary subunit alpha2delta 3
93589  CACNA2D4; calcium voltage-gated channel auxiliary subunit alpha2delta 4
782  CACNB1; calcium voltage-gated channel auxiliary subunit beta 1
783  CACNB2; calcium voltage-gated channel auxiliary subunit beta 2
784  CACNB3; calcium voltage-gated channel auxiliary subunit beta 3
785  CACNB4; calcium voltage-gated channel auxiliary subunit beta 4
786  CACNG1; calcium voltage-gated channel auxiliary subunit gamma 1
10369  CACNG2; calcium voltage-gated channel auxiliary subunit gamma 2
10368  CACNG3; calcium voltage-gated channel auxiliary subunit gamma 3
27092  CACNG4; calcium voltage-gated channel auxiliary subunit gamma 4
27091  CACNG5; calcium voltage-gated channel auxiliary subunit gamma 5
59285  CACNG6; calcium voltage-gated channel auxiliary subunit gamma 6
59284  CACNG7; calcium voltage-gated channel auxiliary subunit gamma 7
6262  RYR2; ryanodine receptor 2
10345  TRDN; triadin
444  ASPH; aspartate beta-hydroxylase
844  CASQ1; calsequestrin 1
845  CASQ2; calsequestrin 2
Metabolite
C00076  Calcium cation
Reference
PMID:31878335
  Authors
Avila G, de la Rosa JA, Monsalvo-Villegas A, Montiel-Jaen MG
  Title
Ca(2+) Channels Mediate Bidirectional Signaling between Sarcolemma and Sarcoplasmic Reticulum in Muscle Cells.
  Journal
Cells 9:cells9010055 (2019)
DOI:10.3390/cells9010055
Reference
PMID:22435804
  Authors
Berridge MJ
  Title
Calcium signalling remodelling and disease.
  Journal
Biochem Soc Trans 40:297-309 (2012)
DOI:10.1042/BST20110766
Reference
PMID:25569087
  Authors
Gehlert S, Bloch W, Suhr F
  Title
Ca2+-dependent regulations and signaling in skeletal muscle: from electro-mechanical coupling to adaptation.
  Journal
Int J Mol Sci 16:1066-95 (2015)
DOI:10.3390/ijms16011066
Reference
PMID:34208776
  Authors
Maggi L, Bonanno S, Altamura C, Desaphy JF
  Title
Ion Channel Gene Mutations Causing Skeletal Muscle Disorders: Pathomechanisms and Opportunities for Therapy.
  Journal
Cells 10:cells10061521 (2021)
DOI:10.3390/cells10061521
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