KEGG   NETWORK: N01759
Entry
N01759                      Network                                
Name
INK1-Parkin-mediated MFN2 degradation, VCP-OPA1
Definition
VCP -| MFN1/2 == OPA1
  Expanded
7415 -| (55669,9927) == 4976
Class
nt06536 Mitophagy
Type
Reference
Pathway
hsa04137  Mitophagy - animal
Gene
7415  VCP; valosin containing protein
55669  MFN1; mitofusin 1
9927  MFN2; mitofusin 2
4976  OPA1; OPA1 mitochondrial dynamin like GTPase
Reference
PMID:29676259
  Authors
McLelland GL, Goiran T, Yi W, Dorval G, Chen CX, Lauinger ND, Krahn AI, Valimehr S, Rakovic A, Rouiller I, Durcan TM, Trempe JF, Fon EA
  Title
Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy.
  Journal
Elife 7:e32866 (2018)
DOI:10.7554/eLife.32866
Reference
PMID:23498974
  Authors
Kim NC, Tresse E, Kolaitis RM, Molliex A, Thomas RE, Alami NH, Wang B, Joshi A, Smith RB, Ritson GP, Winborn BJ, Moore J, Lee JY, Yao TP, Pallanck L, Kundu M, Taylor JP
  Title
VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations.
  Journal
Neuron 78:65-80 (2013)
DOI:10.1016/j.neuron.2013.02.029
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