Homo sapiens (human): 4976
Help
Entry
4976 CDS
T01001
Symbol
OPA1, BERHS, MGM1, MTDPS14, NPG, NTG, largeG
Name
(RefSeq) OPA1 mitochondrial dynamin like GTPase
KO
K17079
optic atrophy protein 1 [EC:
3.6.5.5
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04137
Mitophagy - animal
hsa05017
Spinocerebellar ataxia
Network
nt06536
Mitophagy
Element
N01759
INK1-Parkin-mediated MFN2 degradation, VCP-OPA1
Disease
H00469
Mitochondrial DNA depletion syndrome
H01020
Optic atrophy
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09141 Transport and catabolism
04137 Mitophagy - animal
4976 (OPA1)
09160 Human Diseases
09164 Neurodegenerative disease
05017 Spinocerebellar ataxia
4976 (OPA1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03029 Mitochondrial biogenesis [BR:
hsa03029
]
4976 (OPA1)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.6 Acting on acid anhydrides
3.6.5 Acting on GTP to facilitate cellular and subcellular movement
3.6.5.5 dynamin GTPase
4976 (OPA1)
Mitochondrial biogenesis [BR:
hsa03029
]
Mitochondrial quality control factors
Mitochondrial dynamics
Fission and Fusion factors
4976 (OPA1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
OPA1_C
Dynamin_N
MMR_HSR1
FeoB_N
Sde182_NH-like
Roc
DUF2267
Ephrin_rec_like
Motif
Other DBs
NCBI-GeneID:
4976
NCBI-ProteinID:
NP_056375
OMIM:
605290
HGNC:
8140
Ensembl:
ENSG00000198836
Pharos:
O60313
(Tbio)
UniProt:
O60313
Structure
PDB
PDBj
LinkDB
All DBs
Position
3:193593208..193697811
Genome browser
AA seq
960 aa
AA seq
DB search
MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQ
QFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFD
QWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLK
DFFTSGSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKEN
KELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAG
KTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALR
HEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFS
ISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPS
RIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVT
TRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFEKAKNE
ILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQW
TDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAED
SLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKN
RTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQV
YRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTN
TEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK
NT seq
2883 nt
NT seq
+upstream
nt +downstream
nt
atgtggcgactacgtcgggccgctgtggcctgtgaggtctgccagtctttagtgaaacac
agctctggaataaaaggaagtttaccactacaaaaactacatctggtttcacgaagcatt
tatcattcacatcatcctaccttaaagcttcaacgaccccaattaaggacatcctttcag
cagttctcttctctgacaaaccttcctttacgtaaactgaaattctctccaattaaatat
ggctaccagcctcgcaggaatttttggccagcaagattagctacgagactcttaaaactt
cgctatctcatactaggatcggctgttgggggtggctacacagccaaaaagacttttgat
cagtggaaagatatgataccggaccttagtgaatataaatggattgtgcctgacattgtg
tgggaaattgatgagtatatcgattttgagaaaattagaaaagcccttcctagttcagaa
gaccttgtaaagttagcaccagactttgacaagattgttgaaagccttagcttattgaag
gacttttttacctcaggttctccggaagaaacggcgtttagagcaacagatcgtggatct
gaaagtgacaagcattttagaaaggtgtcagacaaagagaaaattgaccaacttcaggaa
gaacttctgcacactcagttgaagtatcagagaatcttggaacgattagaaaaggagaac
aaagaattgagaaaattagtattgcagaaagatgacaaaggcattcatcatagaaagctt
aagaaatctttgattgacatgtattctgaagttcttgatgttctctctgattatgatgcc
agttataatacgcaagatcatctgccacgggttgttgtggttggagatcagagtgctgga
aagactagtgtgttggaaatgattgcccaagctcgaatattcccaagaggatctggggag
atgatgacacgttctccagttaaggtgactctgagtgaaggtcctcaccatgtggcccta
tttaaagatagttctcgggagtttgatcttaccaaagaagaagatcttgcagcattaaga
catgaaatagaacttcgaatgaggaaaaatgtgaaagaaggctgtaccgttagccctgag
accatatccttaaatgtaaaaggccctggactacagaggatggtgcttgttgacttacca
ggtgtgattaatactgtgacatcaggcatggctcctgacacaaaggaaactattttcagt
atcagcaaagcttacatgcagaatcctaatgccatcatactgtgtattcaagatggatct
gtggatgctgaacgcagtattgttacagacttggtcagtcaaatggaccctcatggaagg
agaaccatattcgttttgaccaaagtagacctggcagagaaaaatgtagccagtccaagc
aggattcagcagataattgaaggaaagctcttcccaatgaaagctttaggttattttgct
gttgtaacaggaaaagggaacagctctgaaagcattgaagctataagagaatatgaagaa
gagttttttcagaattcaaagctcctaaagacaagcatgctaaaggcacaccaagtgact
acaagaaatttaagccttgcagtatcagactgcttttggaaaatggtacgagagtctgtt
gaacaacaggctgatagtttcaaagcaacacgttttaaccttgaaactgaatggaagaat
aactatcctcgcctgcgggaacttgaccggaatgaactatttgaaaaagctaaaaatgaa
atccttgatgaagttatcagtctgagccaggttacaccaaaacattgggaggaaatcctt
caacaatctttgtgggaaagagtatcaactcatgtgattgaaaacatctaccttccagct
gcgcagaccatgaattcaggaacttttaacaccacagtggatatcaagcttaaacagtgg
actgataaacaacttcctaataaagcagtagaggttgcttgggagaccctacaagaagaa
ttttcccgctttatgacagaaccgaaagggaaagagcatgatgacatatttgataaactt
aaagaggctgttaaggaagaaagtattaaacgacacaagtggaatgactttgcggaggac
agcttgagggttattcaacacaatgctttggaagaccgatccatatctgataaacagcaa
tgggatgcagctatttattttatggaagaggctctgcaggctcgtctcaaggatactgaa
aatgcaattgaaaacatggtgggtccagactggaaaaagaggtggttatactggaagaat
cggacccaagaacagtgtgttcacaatgaaaccaagaatgaattggagaagatgttgaaa
tgtaatgaggagcacccagcttatcttgcaagtgatgaaataaccacagtccggaagaac
cttgaatcccgaggagtagaagtagatccaagcttgattaaggatacttggcatcaagtt
tatagaagacattttttaaaaacagctctaaaccattgtaacctttgtcgaagaggtttt
tattactaccaaaggcattttgtagattctgagttggaatgcaatgatgtggtcttgttt
tggcgtatacagcgcatgcttgctatcaccgcaaatactttaaggcaacaacttacaaat
actgaagttaggcgattagagaaaaatgttaaagaggtattggaagattttgctgaagat
ggtgagaagaagattaaattgcttactggtaaacgcgttcaactggcggaagacctcaag
aaagttagagaaattcaagaaaaacttgatgctttcattgaagctcttcatcaggagaaa
taa
DBGET
integrated database retrieval system
