Homo sapiens (human): 55669
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Entry
55669 CDS
T01001
Symbol
MFN1, hfzo1, hfzo2
Name
(RefSeq) mitofusin 1
KO
K21356
mitofusin 1 [EC:3.6.5.-]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04137
Mitophagy - animal
hsa04621
NOD-like receptor signaling pathway
hsa05012
Parkinson disease
hsa05022
Pathways of neurodegeneration - multiple diseases
Network
nt06463
Parkinson disease
nt06466
Pathways of neurodegeneration
nt06536
Mitophagy
Element
N01052
PINK1-Parkin-mediated MFN2 degradation
N01053
Mutation-inactivated PINK1 to PINK1-Parkin-mediated MFN2 degradation
N01054
Mutation-inactivated PRKN to PINK1-Parkin-mediated MFN2 degradation
N01756
PINK-Parkin-independent ubiquitin-mediated mitophagy
N01759
INK1-Parkin-mediated MFN2 degradation, VCP-OPA1
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09141 Transport and catabolism
04137 Mitophagy - animal
55669 (MFN1)
09150 Organismal Systems
09151 Immune system
04621 NOD-like receptor signaling pathway
55669 (MFN1)
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
55669 (MFN1)
05022 Pathways of neurodegeneration - multiple diseases
55669 (MFN1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03029 Mitochondrial biogenesis [BR:
hsa03029
]
55669 (MFN1)
Mitochondrial biogenesis [BR:
hsa03029
]
Mitochondrial quality control factors
Mitochondrial dynamics
Fission and Fusion factors
55669 (MFN1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Fzo_mitofusin
Dynamin_N
MMR_HSR1
Motif
Other DBs
NCBI-GeneID:
55669
NCBI-ProteinID:
NP_284941
OMIM:
608506
HGNC:
18262
Ensembl:
ENSG00000171109
UniProt:
Q8IWA4
Structure
PDB
PDBj
LinkDB
All DBs
Position
3:179347709..179394936
Genome browser
AA seq
741 aa
AA seq
DB search
MAEPVSPLKHFVLAKKAITAIFDQLLEFVTEGSHFVEATYKNPELDRIATEDDLVEMQGY
KDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNCFLSVEGTDG
DKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVRVFWPKAKCALLRDDLVLVDSP
GTDVTTELDSWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWD
ASASEPEYMEDVRRQHMERCLHFLVEELKVVNALEAQNRIFFVSAKEVLSARKQKAQGMP
ESGVALAEGFHARLQEFQNFEQIFEECISQSAVKTKFEQHTIRAKQILATVKNIMDSVNL
AAEDKRHYSVEEREDQIDRLDFIRNQMNLLTLDVKKKIKEVTEEVANKVSCAMTDEICRL
SVLVDEFCSEFHPNPDVLKIYKSELNKHIEDGMGRNLADRCTDEVNALVLQTQQEIIENL
KPLLPAGIQDKLHTLIPCKKFDLSYNLNYHKLCSDFQEDIVFRFSLGWSSLVHRFLGPRN
AQRVLLGLSEPIFQLPRSLASTPTAPTTPATPDNASQEELMITLVTGLASVTSRTSMGII
IVGGVIWKTIGWKLLSVSLTMYGALYLYERLSWTTHAKERAFKQQFVNYATEKLRMIVSS
TSANCSHQVKQQIATTFARLCQQVDITQKQLEEEIARLPKEIDQLEKIQNNSKLLRNKAV
QLENELENFTKQFLPSSNEES
NT seq
2226 nt
NT seq
+upstream
nt +downstream
nt
atggcagaacctgtttctccactgaagcactttgtgctggctaagaaggcgattactgca
atctttgaccagttactggagtttgttactgaaggatcacattttgttgaagcaacatat
aagaatccggaacttgatcgaatagccactgaagatgatctggtagaaatgcaaggatat
aaagacaagctttccatcattggtgaggtgctatctcggagacacatgaaggtggcattt
tttggcaggacaagcagtgggaagagctctgttatcaatgcaatgttgtgggataaagtt
ctccctagtgggattggccatataaccaattgcttcctaagtgttgaaggaactgatgga
gataaagcctatcttatgacagaaggatcagatgaaaaaaagagtgtgaagacagttaat
caactggcccatgcccttcacatggacaaagatttgaaagctggctgtcttgtacgtgtg
ttttggccaaaagcaaaatgtgccctcttgagagatgacctggtgttagtagacagtcca
ggcacagatgtcactacagagctggatagctggattgataagttttgcctagatgctgat
gtctttgttttggtcgcaaactctgaatcaacactaatgaatacggaaaaacactttttt
cacaaggtgaatgagcggctttccaagcctaatattttcattctcaataatcgttgggat
gcctctgcatcagagccagaatatatggaagacgtacgcagacagcacatggaaagatgc
ctgcatttcttggtggaggagctcaaagttgtaaatgctttagaagcacagaatcgtatc
ttctttgtttcagcaaaggaagttcttagtgctagaaagcaaaaagcacaggggatgcca
gaaagtggtgtggcacttgctgaaggatttcatgcaagattacaggaatttcagaatttt
gaacaaatctttgaggagtgtatctcgcagtcagcagtgaaaacaaagttcgaacagcac
actatcagagctaaacagatactagctactgtgaaaaacataatggattcagtaaacctg
gcagctgaagataaaaggcattattcagtggaagagagggaagaccaaattgatagactg
gactttattcgaaaccagatgaaccttttaacactggatgttaagaaaaaaatcaaggag
gttaccgaggaggtggcaaacaaagtttcatgtgcaatgacagatgaaatttgtcgactg
tctgttttggttgatgaattttgttcagagtttcatcctaatccagatgtattaaaaata
tataaaagtgaattaaataagcacatagaggatggtatgggaagaaatttggctgatcga
tgcaccgatgaagtaaacgccttagtgcttcagacccagcaagaaattattgaaaatttg
aagccattacttccagctggtatacaggataaactacatacactgatcccttgcaagaaa
tttgatctcagttataatctaaattaccacaagttatgttcagattttcaagaggatatt
gtatttcgtttttccctgggctggtcttcccttgtacatcgatttttgggccctagaaat
gctcaaagggtgctcctaggattatcagagcctatctttcagctccctagatctttagct
tctactcccactgctcctaccactccagcaacgccagataatgcatcacaggaagaactc
atgattacattagtaacaggattggcgtccgttacatctagaacttctatgggcatcatt
attgttggaggagtgatttggaaaactataggctggaaactcctatctgtttcattaact
atgtatggagctttgtatctttatgaaagactgagctggaccacccatgccaaggagcga
gcctttaaacagcagtttgtaaactatgcaactgaaaaactgaggatgattgttagctcc
acgagtgcaaactgcagtcaccaagtaaaacaacaaatagctaccacttttgctcgcctg
tgccaacaagttgatattactcaaaaacagctggaagaagaaattgctagattacccaaa
gaaatagatcagttggagaaaatacaaaacaattcaaagctcttaagaaataaagctgtt
caacttgaaaatgagctggagaattttactaagcagtttctaccttcaagcaatgaagaa
tcctaa
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integrated database retrieval system
