KEGG   NETWORK: N01779
Entry
N01779                      Network                                
Name
Continual efferocytosis enhanced by the AC-derived arginine and ornithine
Definition
Arg(lyso)+PQLC2 -> Arg(cyto) -- ARG1 -> Orn -- ODC1 -> Put -> RAC1
  Expanded
C00062+54896 -> C00062 -- 383 -> C00077 -- 4953 -> C00134 -> 5879
Class
nt06535 Efferocytosis
Type
Reference
Pathway
hsa04148 Efferocytosis   
Gene
54896  SLC66A1; solute carrier family 66 member 1
383  ARG1; arginase 1
4953  ODC1; ornithine decarboxylase 1
5879  RAC1; Rac family small GTPase 1
Metabolite
C00062  L-Arginine
C00077  L-Ornithine
C00134  Putrescine
Reference
PMID:32004476
  Authors
Yurdagul A Jr, Subramanian M, Wang X, Crown SB, Ilkayeva OR, Darville L, Kolluru GK, Rymond CC, Gerlach BD, Zheng Z, Kuriakose G, Kevil CG, Koomen JM, Cleveland JL, Muoio DM, Tabas I
  Title
Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury.
  Journal
Cell Metab 31:518-533.e10 (2020)
DOI:10.1016/j.cmet.2020.01.001
Reference
PMID:33927896
  Authors
Yurdagul A Jr
  Title
Metabolic Consequences of Efferocytosis and its Impact on Atherosclerosis.
  Journal
Immunometabolism 3:e210017 (2021)
DOI:10.20900/immunometab20210017
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