Homo sapiens (human): 383 Help Entry 383               CDS       T01001                                  Symbol ARG1 Name (RefSeq) arginase 1   KO K01476   arginase [EC:3.5.3.1] Organism hsa  Homo sapiens (human) Pathway hsa00220   Arginine biosynthesis hsa00330   Arginine and proline metabolism hsa01100   Metabolic pathways hsa01230   Biosynthesis of amino acids hsa04148   Efferocytosis hsa05146   Amoebiasis Module hsa_M00029   Urea cycle hsa_M00134   Polyamine biosynthesis, arginine => ornithine => putrescine Network nt06010  Urea cycle nt06535  Efferocytosis   Element N00593   Urea cycle N01779   Continual efferocytosis enhanced by the AC-derived arginine and ornithine Disease H00186   Hyperargininemia H01398   Primary hyperammonemia (Urea cycle disorders) Drug target Numidargistat:  D11792 Pegzilarginase:  D11695 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09105 Amino acid metabolism    00220 Arginine biosynthesis     383 (ARG1)    00330 Arginine and proline metabolism     383 (ARG1)  09140 Cellular Processes   09141 Transport and catabolism    04148 Efferocytosis     383 (ARG1)  09160 Human Diseases   09174 Infectious disease: parasitic    05146 Amoebiasis     383 (ARG1) Enzymes [BR:hsa01000]  3. Hydrolases   3.5  Acting on carbon-nitrogen bonds, other than peptide bonds    3.5.3  In linear amidines     3.5.3.1  arginase      383 (ARG1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Arginase Motif Other DBs NCBI-GeneID:  383 NCBI-ProteinID:  NP_000036 OMIM:  608313 HGNC:  663 Ensembl:  ENSG00000118520 Pharos:  P05089(Tchem) UniProt:  P05089 Structure PDBPDBj LinkDB All DBs Position 6:131573226..131584329 Genome browser AA seq 322 aa AA seqDB search MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGV IWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLR DVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT LACFGLAREGNHKPIDYLNPPK NT seq 969 nt NT seq  +upstreamnt  +downstreamnt atgagcgccaagtccagaaccatagggattattggagctcctttctcaaagggacagcca cgaggaggggtggaagaaggccctacagtattgagaaaggctggtctgcttgagaaactt aaagaacaagagtgtgatgtgaaggattatggggacctgccctttgctgacatccctaat gacagtccctttcaaattgtgaagaatccaaggtctgtgggaaaagcaagcgagcagctg gctggcaaggtggcagaagtcaagaagaacggaagaatcagcctggtgctgggcggagac cacagtttggcaattggaagcatctctggccatgccagggtccaccctgatcttggagtc atctgggtggatgctcacactgatatcaacactccactgacaaccacaagtggaaacttg catggacaacctgtatctttcctcctgaaggaactaaaaggaaagattcccgatgtgcca ggattctcctgggtgactccctgtatatctgccaaggatattgtgtatattggcttgaga gacgtggaccctggggaacactacattttgaaaactctaggcattaaatacttttcaatg actgaagtggacagactaggaattggcaaggtgatggaagaaacactcagctatctacta ggaagaaagaaaaggccaattcatctaagttttgatgttgacggactggacccatctttc acaccagctactggcacaccagtcgtgggaggtctgacatacagagaaggtctctacatc acagaagaaatctacaaaacagggctactctcaggattagatataatggaagtgaaccca tccctggggaagacaccagaagaagtaactcgaacagtgaacacagcagttgcaataacc ttggcttgtttcggacttgctcgggagggtaatcacaagcctattgactaccttaaccca cctaagtaa

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